AIM: To investigate the relationship between the -765G > C COX-2 polymorphism and the development of different gastric lesions: atrophy or intestinal metaplasia and gastric adenocarcinoma. METHODS: A cross-sectional study was performed involving 320 Portuguese individuals (210 without evidence of neoplastic disease, 73 patients with gastric adenocarcinomas and 37 with atrophy or intestinal metaplasia) using a PCR-RFLP method. RESULTS: -765C allele was overrepresented in the patients with gastric adenocarcinoma (51%) when compared either with the control group (38%) or patients with atrophy or intestinal metaplasia (27%). Callele was found to be very common in our population (0.22), and a multivariate logistic regression analysis revealed nearly 3-fold increased risk for the progression to gastric adenocarcinoma in patients with atrophy or intestinal metaplasia carrying the -765C allele (OR = 2.67, 95% CI = 1.03-6.93; P = 0.04). CONCLUSION: -765C carrier status should be considered as another susceptibility marker for gastric adenocarcinoma development in patients with atrophy or intestinal metaplasia.
AIM: To investigate the relationship between the -765G > C COX-2 polymorphism and the development of different gastric lesions: atrophy or intestinal metaplasia and gastric adenocarcinoma. METHODS: A cross-sectional study was performed involving 320 Portuguese individuals (210 without evidence of neoplastic disease, 73 patients with gastric adenocarcinomas and 37 with atrophy or intestinal metaplasia) using a PCR-RFLP method. RESULTS: -765C allele was overrepresented in the patients with gastric adenocarcinoma (51%) when compared either with the control group (38%) or patients with atrophy or intestinal metaplasia (27%). Callele was found to be very common in our population (0.22), and a multivariate logistic regression analysis revealed nearly 3-fold increased risk for the progression to gastric adenocarcinoma in patients with atrophy or intestinal metaplasia carrying the -765C allele (OR = 2.67, 95% CI = 1.03-6.93; P = 0.04). CONCLUSION: -765C carrier status should be considered as another susceptibility marker for gastric adenocarcinoma development in patients with atrophy or intestinal metaplasia.
Authors: Isabel Duarte; Alexandra Santos; Hugo Sousa; Raquel Catarino; Daniela Pinto; Ana Matos; Deolinda Pereira; José Moutinho; Paulo Canedo; José Carlos Machado; Rui Medeiros Journal: Biochem Biophys Res Commun Date: 2005-08-26 Impact factor: 3.575
Authors: P M Ferreira; R Medeiros; A Vasconcelos; S Costa; D Pinto; A Morais; J Oliveira; C Lopes Journal: Eur J Cancer Prev Date: 2003-06 Impact factor: 2.497
Authors: M Dinis-Ribeiro; C Lopes; A da Costa-Pereira; M Guilherme; J Barbosa; H Lomba-Viana; R Silva; L Moreira-Dias Journal: J Clin Pathol Date: 2004-02 Impact factor: 3.411
Authors: Ana Paula Araújo; Bruno M Costa; Ana L Pinto-Correia; Maria Fragoso; Paula Ferreira; Mário Dinis-Ribeiro; Sandra Costa; Rui M Reis; Rui Medeiros Journal: World J Gastroenterol Date: 2011-01-28 Impact factor: 5.742
Authors: In Jai Kim; Sang Hoon Kim; Dong Hoon Cha; Sang Wook Lim; Jae Youn Moon; Jung Oh Kim; Chang Soo Ryu; Han Sung Park; Jung Hoon Sung; Nam Keun Kim Journal: Genes Genomics Date: 2019-06-05 Impact factor: 1.839