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Literature DB >> 16079228

A statistical multiprobe model for analyzing cis and trans genes in genetical genomics experiments with short-oligonucleotide arrays.

Rudi Alberts¹, Peter Terpstra, Leonid V Bystrykh, Gerald de Haan, Ritsert C Jansen.

Abstract

Short-oligonucleotide arrays typically contain multiple probes per gene. In genetical genomics applications a statistical model for the individual probe signals can help in separating "true" differential mRNA expression from "ghost" effects caused by polymorphisms, misdesigned probes, and batch effects. It can also help in detecting alternative splicing, start, or termination.

Entities: Chemical

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Year: 2005 PMID： 16079228 PMCID： PMC1456841 DOI： 10.1534/genetics.105.045930

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

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