Literature DB >> 16078827

A positron emission tomography radioligand for the in vivo labeling of metabotropic glutamate 1 receptor: (3-ethyl-2-[11C]methyl-6-quinolinyl)(cis- 4-methoxycyclohexyl)methanone.

Yiyun Huang1, Raj Narendran, François Bischoff, Ningning Guo, Zhihong Zhu, Sung-A Bae, Anne S Lesage, Marc Laruelle.   

Abstract

A selective metabotropic glutamate 1 receptor (mGlu1) antagonist was labeled with the positron-emitting radioisotope carbon-11 and evaluated in ex vivo biodistribution studies and micro-positron emission tomography (micro-PET) imaging experiments in rats. Results from animal experiments demonstrate that the radioligand [11C]2 is the first PET tracer capable of labeling the rat mGlu1 receptor in vivo.

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Year:  2005        PMID： 16078827     DOI： 10.1021/jm050263+

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  11 in total

Review 1.  GCPII imaging and cancer.

Authors:  C A Foss; R C Mease; S Y Cho; H J Kim; M G Pomper
Journal:  Curr Med Chem       Date:  2012       Impact factor: 4.530

2.  Imaging for metabotropic glutamate receptor subtype 1 in rat and monkey brains using PET with [18F]FITM.

Authors:  Tomoteru Yamasaki; Masayuki Fujinaga; Jun Maeda; Kazunori Kawamura; Joji Yui; Akiko Hatori; Yuichiro Yoshida; Yuji Nagai; Masaki Tokunaga; Makoto Higuchi; Tetsuya Suhara; Toshimitsu Fukumura; Ming-Rong Zhang
Journal:  Eur J Nucl Med Mol Imaging       Date:  2011-11-24       Impact factor: 9.236

3.  Synthesis, in vitro and in vivo evaluation of [11C]MMTP: a potential PET ligand for mGluR1 receptors.

Authors:  Jaya Prabhakaran; Vattoly J Majo; Matthew S Milak; Suham A Kassir; Mikael Palner; Lyudmila Savenkova; Pratap Mali; Victoria Arango; J John Mann; Ramin V Parsey; J S Dileep Kumar
Journal:  Bioorg Med Chem Lett       Date:  2010-05-05       Impact factor: 2.823

4.  Preclinical anaylses of [18F]cEFQ as a PET tracer for imaging metabotropic glutamate receptor type 1 (mGluR1).

Authors:  Boeun Lee; Yu Kyeong Kim; Ji Youn Lee; Young Joo Kim; Yun-Sang Lee; Dong Soo Lee; June-Key Chung; Jae Min Jeong
Journal:  J Cereb Blood Flow Metab       Date:  2016-01-01       Impact factor: 6.200

5.  Synthesis and evaluation in monkey of [(18)F]4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide ([(18)F]FIMX): a promising radioligand for PET imaging of brain metabotropic glutamate receptor 1 (mGluR1).

Authors:  Rong Xu; Paolo Zanotti-Fregonara; Sami S Zoghbi; Robert L Gladding; Alicia E Woock; Robert B Innis; Victor W Pike
Journal:  J Med Chem       Date:  2013-11-07       Impact factor: 7.446

6.  Evaluation in vitro and in animals of a new 11C-labeled PET radioligand for metabotropic glutamate receptors 1 in brain.

Authors:  Paolo Zanotti-Fregonara; Vanessa N Barth; Jeih-San Liow; Sami S Zoghbi; David T Clark; Emily Rhoads; Edward Siuda; Beverly A Heinz; Eric Nisenbaum; Bruce Dressman; Elizabeth Joshi; Debra Luffer-Atlas; Matthew J Fisher; John J Masters; Nancy Goebl; Steven L Kuklish; Cheryl Morse; Johannes Tauscher; Victor W Pike; Robert B Innis
Journal:  Eur J Nucl Med Mol Imaging       Date:  2012-11-08       Impact factor: 9.236

7.  2-(2'-((dimethylamino)methyl)-4'-(fluoroalkoxy)-phenylthio)benzenamine derivatives as serotonin transporter imaging agents.

Authors:  Ajit K Parhi; Julie L Wang; Shunichi Oya; Seok-Rye Choi; Mei-Ping Kung; Hank F Kung
Journal:  J Med Chem       Date:  2007-12-04       Impact factor: 7.446

Review 8.  Development of PET and SPECT probes for glutamate receptors.

Authors:  Takeshi Fuchigami; Morio Nakayama; Sakura Yoshida
Journal:  ScientificWorldJournal       Date:  2015-03-22

9.  11C-LY2428703, a positron emission tomographic radioligand for the metabotropic glutamate receptor 1, is unsuitable for imaging in monkey and human brains.

Authors:  Paolo Zanotti-Fregonara; Vanessa N Barth; Sami S Zoghbi; Jeih-San Liow; Eric Nisenbaum; Edward Siuda; Robert L Gladding; Denise Rallis-Frutos; Cheryl Morse; Johannes Tauscher; Victor W Pike; Robert B Innis
Journal:  EJNMMI Res       Date:  2013-06-10       Impact factor: 3.138

Review 10.  Small Molecule Radiopharmaceuticals - A Review of Current Approaches.

Authors:  Shubhra Chaturvedi; Anil K Mishra
Journal:  Front Med (Lausanne)       Date:  2016-02-23
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