Literature DB >> 16076156

Simple fluorescent pyrimidine analogues detect the presence of DNA abasic sites.

Nicholas J Greco1, Yitzhak Tor.   

Abstract

A family of simple pyrimidine analogues has been synthesized, and their photophysical properties have been investigated. The most responsive of the family was incorporated in DNA. This isosteric fluorescent DNA analogue monitors denaturation of a DNA duplex via fluorescence and positively detects the presence of abasic sites in DNA duplexes.

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Year:  2005        PMID： 16076156     DOI： 10.1021/ja052000a

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  51 in total

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Authors:  Mary S Noé; Andro C Ríos; Yitzhak Tor
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3.  Modified 6-aza uridines: highly emissive pH-sensitive fluorescent nucleosides.

Authors:  Renatus W Sinkeldam; Patrycja A Hopkins; Yitzhak Tor
Journal:  Chemphyschem       Date:  2012-07-06       Impact factor: 3.102

4.  Synthesis and properties of size-expanded DNAs: toward designed, functional genetic systems.

Authors:  Andrew T Krueger; Haige Lu; Alex H F Lee; Eric T Kool
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5.  Fluorescent pyrimidine ribonucleotide: synthesis, enzymatic incorporation, and utilization.

Authors:  Seergazhi G Srivatsan; Yitzhak Tor
Journal:  J Am Chem Soc       Date:  2007-01-26       Impact factor: 15.419

6.  Fluorescent 5-Pyrimidine and 8-Purine Nucleosides Modified with an N-Unsubstituted 1,2,3-Triazol-4-yl Moiety.

Authors:  Zhiwei Wen; Paloma R Tuttle; A Hasan Howlader; Anna Vasilyeva; Laura Gonzalez; Antonija Tangar; Ruipeng Lei; Eduardo E Laverde; Yuan Liu; Jaroslava Miksovska; Stanislaw F Wnuk
Journal:  J Org Chem       Date:  2019-03-06       Impact factor: 4.354

7.  Enzymatic interconversion of isomorphic fluorescent nucleosides: adenosine deaminase transforms an adenosine analogue into an inosine analogue.

Authors:  Renatus W Sinkeldam; Lisa S McCoy; Dongwon Shin; Yitzhak Tor
Journal:  Angew Chem Int Ed Engl       Date:  2013-11-29       Impact factor: 15.336

8.  Enzymatic incorporation of emissive pyrimidine ribonucleotides.

Authors:  Seergazhi G Srivatsan; Yitzhak Tor
Journal:  Chem Asian J       Date:  2009-03-02

9.  FRET enabled real time detection of RNA-small molecule binding.

Authors:  Yun Xie; Andrew V Dix; Yitzhak Tor
Journal:  J Am Chem Soc       Date:  2009-12-09       Impact factor: 15.419

10.  A highly fluorescent nucleoside analog based on thieno[3,4-d]pyrimidine senses mismatched pairing.

Authors:  Seergazhi G Srivatsan; Haim Weizman; Yitzhak Tor
Journal:  Org Biomol Chem       Date:  2008-03-10       Impact factor: 3.876
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