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Literature DB >> 16054239

The histamine H4 receptor as a new therapeutic target for inflammation.

Iwan J P de Esch¹, Robin L Thurmond, Aldo Jongejan, Rob Leurs.

Abstract

Following the sequencing of the human genome, data-mining efforts have revealed the existence of a new histamine receptor that is expressed at high levels in mast cells and leukocytes. The histamine H(4) receptor has a distinct pharmacological profile and the first compounds that act selectively on the H(4) receptor have been developed. Initial experiments in vivo with H(4) receptor antagonists indicate a role for the H(4) receptor in inflammatory conditions.

Entities: Disease Gene Species

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Year: 2005 PMID： 16054239 DOI： 10.1016/j.tips.2005.07.002

Source DB: PubMed Journal: Trends Pharmacol Sci ISSN： 0165-6147 Impact factor: 14.819

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Cited

49 in total

1. Commercially available antibodies against human and murine histamine H₄-receptor lack specificity.

Authors: Silke Beermann; Roland Seifert; Detlef Neumann
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2011-11-10 Impact factor: 3.000

2. Effects of sympathetic histamine on vasomotor responses of blood vessels in rabbit ear to electrical stimulation.

Authors: Ying-Ying Chen; Jun Lv; Xiao-Yan Xue; Gong-Hao He; Ying Zhou; Min Jia; Xiao-Xing Luo
Journal: Neurosci Bull Date: 2010-06 Impact factor: 5.203

Review 3. Central nervous system biogenic amine targets for control of appetite and energy expenditure.

Authors: David L Nelson; Donald R Gehlert
Journal: Endocrine Date: 2006-02 Impact factor: 3.633

4. Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives.

Authors: Florence Gbahou; Ludwig Vincent; Marie Humbert-Claude; Joel Tardivel-Lacombe; Claude Chabret; Jean-Michel Arrang
Journal: Br J Pharmacol Date: 2006-04 Impact factor: 8.739

The histamine H4 receptor as a new therapeutic target for inflammation.

1. Commercially available antibodies against human and murine histamine H₄-receptor lack specificity.

2. Effects of sympathetic histamine on vasomotor responses of blood vessels in rabbit ear to electrical stimulation.

Review 3. Central nervous system biogenic amine targets for control of appetite and energy expenditure.

4. Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives.

5. Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors.

Review 6. Molecular and biochemical pharmacology of the histamine H4 receptor.

7. Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function.

8. Therapeutic potential of histamine H₄ receptor agonists in triple-negative human breast cancer experimental model.

9. Sequential engagement of FcεRI on Mast Cells and Basophil Histamine H(4) Receptor and FcεRI in Allergic Rhinitis.

10. Role of a histamine 4 receptor as an anti-inflammatory target in carrageenan-induced pleurisy in mice.