| Literature DB >> 16043338 |
Hans Leemhuis1, Viktor Stein, Andrew D Griffiths, Florian Hollfelder.
Abstract
The key practical consideration in directed evolution of functional biomolecules is the linkage of genotype and phenotype. In vitro selections offer the potential to select from libraries with up to 10(10)-10(14) members, with fewer constraints than current cell-based selections. New approaches such as mRNA display, ribosome display and in vitro compartmentalisation have complementary areas of application in selections for binding or catalysis.Mesh：
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Year: 2005 PMID： 16043338 DOI： 10.1016/j.sbi.2005.07.006
Source DB: PubMed Journal: Curr Opin Struct Biol ISSN： 0959-440X Impact factor: 6.809