Literature DB >> 16038559

3-Nitropropionic acid (3-NPA), a potent antimycobacterial agent from endophytic fungi: is 3-NPA in some plants produced by endophytes?

Porntep Chomcheon1, Suthep Wiyakrutta, Nongluksna Sriubolmas, Nattaya Ngamrojanavanich, Duangnate Isarangkul, Prasat Kittakoop.   

Abstract

3-Nitropropionic acid (3-NPA, 1) was found in extracts of several strains of endophytic fungi. 3-NPA (1) exhibited potent antimycobacterial activity with the minimum inhibition concentration of 3.3 microM, but was inactive against NCI-H187, BC, KB, and Vero cell lines. Endophytes were found to produce high levels of 3-NPA (1), and therefore 3-NPA (1) accumulated in certain plants may be produced by the associated endophytes. 3-NPA (1) may be used as a chemotaxonomic marker for endophytic fungi. The structure of 3-hydroxypropionic acid, a nematicidal agent, should be revised to 3-NPA (1).

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Year:  2005        PMID： 16038559     DOI： 10.1021/np050036a

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  10 in total

1.  Acanthamoebicidal activity of Fusarium sp. Tlau3, an endophytic fungus from Thunbergia laurifolia Lindl.

Authors:  Narumon Boonman; Suthep Wiyakrutta; Nongluksna Sriubolmas; Araya Dharmkrong-at Chusattayanond
Journal:  Parasitol Res       Date:  2008-07-17       Impact factor: 2.289

2.  Production of 3-nitropropionic acid by endophytic fungus Phomopsis longicolla isolated from Trichilia elegans A. JUSS ssp. elegans and evaluation of biological activity.

Authors:  Andressa Caroline Flores; João Alencar Pamphile; Maria Helena Sarragiotto; Edmar Clemente
Journal:  World J Microbiol Biotechnol       Date:  2013-01-08       Impact factor: 3.312

3.  Asperpyrone D and other metabolites of the plant-associated fungal strain Aspergillus tubingensis.

Authors:  Jixun Zhan; G M Kamal B Gunaherath; E M Kithsiri Wijeratne; A A Leslie Gunatilaka
Journal:  Phytochemistry       Date:  2006-12-05       Impact factor: 4.072

4.  The combined structural and kinetic characterization of a bacterial nitronate monooxygenase from Pseudomonas aeruginosa PAO1 establishes NMO class I and II.

Authors:  Francesca Salvi; Johnson Agniswamy; Hongling Yuan; Ken Vercammen; Rudy Pelicaen; Pierre Cornelis; Jim C Spain; Irene T Weber; Giovanni Gadda
Journal:  J Biol Chem       Date:  2014-07-07       Impact factor: 5.157

5.  Phylogenetic and chemical diversity of fungal endophytes isolated from Silybum marianum (L) Gaertn. (milk thistle).

Authors:  Huzefa A Raja; Amninder Kaur; Tamam El-Elimat; Mario Figueroa; Rahul Kumar; Gagan Deep; Rajesh Agarwal; Stanley H Faeth; Nadja B Cech; Nicholas H Oberlies
Journal:  Mycology       Date:  2015-02-23

Review 6.  Endophytic fungi: a reservoir of antibacterials.

Authors:  Sunil K Deshmukh; Shilpa A Verekar; Sarita V Bhave
Journal:  Front Microbiol       Date:  2015-01-08       Impact factor: 5.640

7.  Antiproliferative and Antioxidative Bioactive Compounds in Extracts of Marine-Derived Endophytic Fungus Talaromyces purpureogenus.

Authors:  Madhuree Kumari; Sidhartha Taritla; Ankur Sharma; C Jayabaskaran
Journal:  Front Microbiol       Date:  2018-08-03       Impact factor: 5.640

Review 8.  Fungal Endophytes as Efficient Sources of Plant-Derived Bioactive Compounds and Their Prospective Applications in Natural Product Drug Discovery: Insights, Avenues, and Challenges.

Authors:  Archana Singh; Dheeraj K Singh; Ravindra N Kharwar; James F White; Surendra K Gond
Journal:  Microorganisms       Date:  2021-01-19

9.  Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipata.

Authors:  Karina Andrade de Prince; Renata Sordi; Fernando Rogério Pavan; Adolfo Carlos Barreto Santos; Angela R Araujo; Sergio R A Leite; Clarice Q F Leite
Journal:  Braz J Microbiol       Date:  2012-06-01       Impact factor: 2.476

10.  Two Defensive Lines in Juvenile Leaf Beetles; Esters of 3-nitropropionic Acid in the Hemolymph and Aposematic Warning.

Authors:  Gerhard Pauls; Tobias Becker; Peter Rahfeld; Rene R Gretscher; Christian Paetz; Jacques Pasteels; Stephan H von Reuss; Antje Burse; Wilhelm Boland
Journal:  J Chem Ecol       Date:  2016-03-31       Impact factor: 2.626
  10 in total

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