Literature DB >> 1602962

The suicidal DNA repair methyltransferases of microbes.

L Samson1.   

Abstract

Virtually every organism so far tested has been found to possess an extremely efficient DNA repair mechanism to ensure that certain alkylated oxygens do not accumulate in the genome. The repair is executed by DNA methyltransferases (MTases) which repair DNA O6-methylguanine (O6MeG), O4-methylthymine (O4MeT) and methylphosphotriesters (MePT). The mechanism is rather extravagant because an entire protein molecule is expended for the repair of just one, or sometimes two, O-alkyl DNA adduct(s). Cells profit from such an expensive transaction by earning protection against death and mutation by alkylating agents. This review considers the structure, function and biological roles of a number of well-characterized microbial DNA repair MTases.

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Year:  1992        PMID： 1602962     DOI： 10.1111/j.1365-2958.1992.tb01533.x

Source DB:  PubMed          Journal:  Mol Microbiol        ISSN： 0950-382X            Impact factor:   3.501


  25 in total

1.  Regulated phase transitions of bacterial chromatin: a non-enzymatic pathway for generic DNA protection.

Authors:  D Frenkiel-Krispin; S Levin-Zaidman; E Shimoni; S G Wolf; E J Wachtel; T Arad; S E Finkel; R Kolter; A Minsky
Journal:  EMBO J       Date:  2001-03-01       Impact factor: 11.598

2.  DNA alkylation damage as a sensor of nitrosative stress in Mycobacterium tuberculosis.

Authors:  Steven I Durbach; Burkhard Springer; Edith E Machowski; Robert J North; K G Papavinasasundaram; M Jo Colston; Erik C Böttger; Valerie Mizrahi
Journal:  Infect Immun       Date:  2003-02       Impact factor: 3.441

Review 3.  Regulation by proteolysis: energy-dependent proteases and their targets.

Authors:  S Gottesman; M R Maurizi
Journal:  Microbiol Rev       Date:  1992-12

4.  Repair of damaged bases.

Authors:  Anne Britt
Journal:  Arabidopsis Book       Date:  2002-04-04

5.  A quantum chemical study of repair of O6-methylguanine to guanine by tyrosine: evaluation of the winged helix-turn-helix model.

Authors:  Saumya Tiwari; Phool Chand Mishra
Journal:  J Mol Model       Date:  2009-05-07       Impact factor: 1.810

6.  Conserved residue lysine165 is essential for the ability of O6-alkylguanine-DNA alkyltransferase to react with O6-benzylguanine.

Authors:  M Xu-Welliver; S Kanugula; N A Loktionova; T M Crone; A E Pegg
Journal:  Biochem J       Date:  2000-04-15       Impact factor: 3.857

7.  Point mutations at multiple sites including highly conserved amino acids maintain activity, but render O6-alkylguanine-DNA alkyltransferase insensitive to O6-benzylguanine.

Authors:  M Xu-Welliver; A E Pegg
Journal:  Biochem J       Date:  2000-04-15       Impact factor: 3.857

8.  The role of O(6)-methylguanine-DNA methyltransferase polymorphisms in colorectal cancer susceptibility: a meta analysis.

Authors:  Yongchao Lu; Mingfeng Cao; Kejian Gao; Jinjiao Jiang; Xuewen Shi
Journal:  Int J Clin Exp Med       Date:  2015-01-15

9.  Repair of DNA damage induced by bile salts in Salmonella enterica.

Authors:  Ana I Prieto; Francisco Ramos-Morales; Josep Casadesús
Journal:  Genetics       Date:  2006-08-03       Impact factor: 4.562

10.  DNA alkylation repair limits spontaneous base substitution mutations in Escherichia coli.

Authors:  W J Mackay; S Han; L D Samson
Journal:  J Bacteriol       Date:  1994-06       Impact factor: 3.490
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