Literature DB >> 12540583

DNA alkylation damage as a sensor of nitrosative stress in Mycobacterium tuberculosis.

Steven I Durbach1, Burkhard Springer, Edith E Machowski, Robert J North, K G Papavinasasundaram, M Jo Colston, Erik C Böttger, Valerie Mizrahi.   

Abstract

One of the cellular consequences of nitrosative stress is alkylation damage to DNA. To assess whether nitrosative stress is registered on the genome of Mycobacterium tuberculosis, mutants lacking an alkylation damage repair and reversal operon were constructed. Although hypersensitive to the genotoxic effects of N-methyl-N'-nitro-N-nitrosoguanidine in vitro, the mutants displayed no phenotype in vivo, suggesting that permeation of nitrosative stress to the level of cytotoxic DNA damage is restricted.

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Year:  2003        PMID： 12540583      PMCID： PMC145403          DOI： 10.1128/IAI.71.2.997-1000.2003

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  31 in total

1.  Gene Replacement in Mycobacterium tuberculosis and Mycobacterium bovis BCG Using rpsL as a Dominant Negative Selectable Marker.

Authors:  P Sander; B Springer; E C Böttger
Journal:  Methods Mol Med       Date:  2001

2.  Production of mutants in amino acid biosynthesis genes of Mycobacterium tuberculosis by homologous recombination.

Authors:  T Parish; B G Gordhan; R A McAdam; K Duncan; V Mizrahi; N G Stoker
Journal:  Microbiology       Date:  1999-12       Impact factor: 2.777

3.  rpsL+: a dominant selectable marker for gene replacement in mycobacteria.

Authors:  P Sander; A Meier; E C Böttger
Journal:  Mol Microbiol       Date:  1995-06       Impact factor: 3.501

4.  Functional sites of the Ada regulatory protein of Escherichia coli. Analysis by amino acid substitutions.

Authors:  K Takano; Y Nakabeppu; M Sekiguchi
Journal:  J Mol Biol       Date:  1988-05-20       Impact factor: 5.469

5.  Characterization of spontaneous, In vitro-selected, rifampin-resistant mutants of Mycobacterium tuberculosis strain H37Rv.

Authors:  G P Morlock; B B Plikaytis; J T Crawford
Journal:  Antimicrob Agents Chemother       Date:  2000-12       Impact factor: 5.191

6.  noxR3, a novel gene from Mycobacterium tuberculosis, protects Salmonella typhimurium from nitrosative and oxidative stress.

Authors:  J Ruan; G St John; S Ehrt; L Riley; C Nathan
Journal:  Infect Immun       Date:  1999-07       Impact factor: 3.441

7.  DNA repair in Mycobacterium tuberculosis. What have we learnt from the genome sequence?

Authors:  V Mizrahi; S J Andersen
Journal:  Mol Microbiol       Date:  1998-09       Impact factor: 3.501

8.  Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.

Authors:  S T Cole; R Brosch; J Parkhill; T Garnier; C Churcher; D Harris; S V Gordon; K Eiglmeier; S Gas; C E Barry; F Tekaia; K Badcock; D Basham; D Brown; T Chillingworth; R Connor; R Davies; K Devlin; T Feltwell; S Gentles; N Hamlin; S Holroyd; T Hornsby; K Jagels; A Krogh; J McLean; S Moule; L Murphy; K Oliver; J Osborne; M A Quail; M A Rajandream; J Rogers; S Rutter; K Seeger; J Skelton; R Squares; S Squares; J E Sulston; K Taylor; S Whitehead; B G Barrell
Journal:  Nature       Date:  1998-06-11       Impact factor: 49.962

9.  Regulation of hmp gene transcription in Mycobacterium tuberculosis: effects of oxygen limitation and nitrosative and oxidative stress.

Authors:  Y Hu; P D Butcher; J A Mangan; M A Rajandream; A R Coates
Journal:  J Bacteriol       Date:  1999-06       Impact factor: 3.490

10.  A novel antioxidant gene from Mycobacterium tuberculosis.

Authors:  S Ehrt; M U Shiloh; J Ruan; M Choi; S Gunzburg; C Nathan; Q Xie; L W Riley
Journal:  J Exp Med       Date:  1997-12-01       Impact factor: 14.307
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  17 in total

Review 1.  A new evolutionary and pharmacokinetic-pharmacodynamic scenario for rapid emergence of resistance to single and multiple anti-tuberculosis drugs.

Authors:  Jotam G Pasipanodya; Tawanda Gumbo
Journal:  Curr Opin Pharmacol       Date:  2011-07-30       Impact factor: 5.547

Review 2.  Tuberculosis chemotherapy: the influence of bacillary stress and damage response pathways on drug efficacy.

Authors:  Digby F Warner; Valerie Mizrahi
Journal:  Clin Microbiol Rev       Date:  2006-07       Impact factor: 26.132

3.  The AraC family transcriptional regulator Rv1931c plays a role in the virulence of Mycobacterium tuberculosis.

Authors:  Cristiane C Frota; K G Papavinasasundaram; Elaine O Davis; M Joseph Colston
Journal:  Infect Immun       Date:  2004-09       Impact factor: 3.441

4.  Biochemical and structural studies of the Mycobacterium tuberculosis O6-methylguanine methyltransferase and mutated variants.

Authors:  Riccardo Miggiano; Valentina Casazza; Silvia Garavaglia; Maria Ciaramella; Giuseppe Perugino; Menico Rizzi; Franca Rossi
Journal:  J Bacteriol       Date:  2013-04-05       Impact factor: 3.490

Review 5.  The BER necessities: the repair of DNA damage in human-adapted bacterial pathogens.

Authors:  Stijn van der Veen; Christoph M Tang
Journal:  Nat Rev Microbiol       Date:  2015-01-12       Impact factor: 60.633

6.  The non-clonality of drug resistance in Beijing-genotype isolates of Mycobacterium tuberculosis from the Western Cape of South Africa.

Authors:  Thomas R Ioerger; Yicheng Feng; Xiaohua Chen; Karen M Dobos; Thomas C Victor; Elizabeth M Streicher; Robin M Warren; Nicolaas C Gey van Pittius; Paul D Van Helden; James C Sacchettini
Journal:  BMC Genomics       Date:  2010-11-26       Impact factor: 3.969

7.  Identification of a chemical that inhibits the mycobacterial UvrABC complex in nucleotide excision repair.

Authors:  Nayef Mazloum; Melanie A Stegman; Deborah L Croteau; Bennett Van Houten; Nyoun Soo Kwon; Yan Ling; Caitlyn Dickinson; Aditya Venugopal; Mohammad Atif Towheed; Carl Nathan
Journal:  Biochemistry       Date:  2011-01-31       Impact factor: 3.162

8.  In-Vivo Gene Signatures of Mycobacterium tuberculosis in C3HeB/FeJ Mice.

Authors:  Uma Shankar Gautam; Smriti Mehra; Deepak Kaushal
Journal:  PLoS One       Date:  2015-08-13       Impact factor: 3.240

9.  A non-sense mutation in the putative anti-mutator gene ada/alkA of Mycobacterium tuberculosis and M. bovis isolates suggests convergent evolution.

Authors:  Laurent X Nouvel; Tiago Dos Vultos; Eric Kassa-Kelembho; Jean Rauzier; Brigitte Gicquel
Journal:  BMC Microbiol       Date:  2007-05-16       Impact factor: 3.605

10.  Apurinic/apyrimidinic endonucleases of Mycobacterium tuberculosis protect against DNA damage but are dispensable for the growth of the pathogen in guinea pigs.

Authors:  Rupangi Verma Puri; P Vineel Reddy; Anil K Tyagi
Journal:  PLoS One       Date:  2014-05-06       Impact factor: 3.240
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