PURPOSE: To assess the influence of isoflurane and pentobarbital anesthesia and the carrier gases on myocardial blood flow (MBF) in the rat heart in vivo. MATERIALS AND METHODS: MBF was quantified in vivo using arterial spin-labeling (ASL) magnetic resonance imaging (MRI). Left ventricular (LV) function was estimated during the same experiment using cine-MRI. Thirty-four male Wistar-Kyoto rats were divided in four groups, one anesthetized with isoflurane in oxygen:nitrous oxide mix (ISO), the three others with intraperitoneal pentobarbital, and breathing either room air (PB), oxygen:nitrous oxide (PB + N(2)O), or oxygen:nitrogen (PB + N(2)). RESULTS: MBF was significantly higher in the ISO and PB + N(2)O groups vs. PB and in ISO vs. PB + N(2), with the following respective MBF values: ISO, 5.9 +/- 1.1; PB, 4.0 +/- 0.8; PB + N(2)O, 5.1 +/- 1.4; and PB + N(2), 4.6 +/- 0.8 mL/g/minute, mean +/- SD. Ejection fractions were reduced by 10% in PB and PB + N(2)O rats vs. ISO rats. Cardiac output (CO) and index (CI) were 25 to 30% lower in all rats anesthetized with pentobarbital than with isoflurane. CONCLUSION: Isoflurane and nitrous oxide induce a higher MBF than pentobarbital. Isoflurane also induces a higher ejection fraction in healthy rats. (c) 2005 Wiley-Liss, Inc.
PURPOSE: To assess the influence of isoflurane and pentobarbital anesthesia and the carrier gases on myocardial blood flow (MBF) in the rat heart in vivo. MATERIALS AND METHODS: MBF was quantified in vivo using arterial spin-labeling (ASL) magnetic resonance imaging (MRI). Left ventricular (LV) function was estimated during the same experiment using cine-MRI. Thirty-four male Wistar-Kyoto rats were divided in four groups, one anesthetized with isoflurane in oxygen:nitrous oxide mix (ISO), the three others with intraperitoneal pentobarbital, and breathing either room air (PB), oxygen:nitrous oxide (PB + N(2)O), or oxygen:nitrogen (PB + N(2)). RESULTS: MBF was significantly higher in the ISO and PB + N(2)O groups vs. PB and in ISO vs. PB + N(2), with the following respective MBF values: ISO, 5.9 +/- 1.1; PB, 4.0 +/- 0.8; PB + N(2)O, 5.1 +/- 1.4; and PB + N(2), 4.6 +/- 0.8 mL/g/minute, mean +/- SD. Ejection fractions were reduced by 10% in PB and PB + N(2)Orats vs. ISOrats. Cardiac output (CO) and index (CI) were 25 to 30% lower in all rats anesthetized with pentobarbital than with isoflurane. CONCLUSION:Isoflurane and nitrous oxide induce a higher MBF than pentobarbital. Isoflurane also induces a higher ejection fraction in healthy rats. (c) 2005 Wiley-Liss, Inc.
Authors: Tim Wollenweber; Christian Zach; Christoph Rischpler; Rebekka Fischer; Sebastian Nowak; Stephan G Nekolla; Michael Gröbner; Christopher Ubleis; Gerald Assmann; Josef Müller-Höcker; Christian La Fougére; Guido Böning; Paul Cumming; Wolfgang-Michael Franz; Marcus Hacker Journal: Mol Imaging Biol Date: 2009-11-25 Impact factor: 3.488
Authors: Nick Mark Edward Alexander Hayward; Pasi I Tuunanen; Riikka Immonen; Xavier Ekolle Ndode-Ekane; Asla Pitkänen; Olli Gröhn Journal: J Cereb Blood Flow Metab Date: 2010-05-19 Impact factor: 6.200
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Authors: Nick M E A Hayward; Pavel Yanev; Annakaisa Haapasalo; Riitta Miettinen; Mikko Hiltunen; Olli Gröhn; Jukka Jolkkonen Journal: J Cereb Blood Flow Metab Date: 2010-11-17 Impact factor: 6.200
Authors: Anthony N Price; King K Cheung; Jon O Cleary; Adrienne E Campbell; Johannes Riegler; Mark F Lythgoe Journal: Open Cardiovasc Med J Date: 2010-11-26