| Literature DB >> 11283667 |
Abstract
Polyglutamine diseases comprise a class of familial neurodegenerative disorders caused by expression of proteins containing expanded polyglutamine tracts. Great progress has been made in elucidating the molecular mechanisms contributing to polyglutamine pathology, and in identifying potential drug targets. Although much remains to be learned, these advances provide an opportunity for rational approaches to target-based drug discovery.Entities:
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Year: 2001 PMID： 11283667 DOI： 10.1038/86486
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440