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Literature DB >> 28361262

The interrelationship of metabolic syndrome and neurodegenerative diseases with focus on brain-derived neurotrophic factor (BDNF): Kill two birds with one stone.

Shima Motamedi¹, Isaac Karimi², Fariba Jafari³.

Abstract

The brain-derived neurotrophic factor (BDNF) is involved in metabolic syndrome (MetS) and neurodegenerative diseases (NDD) like Alzheimer's disease, Huntington's disease, Parkinson's disease and depression. If one factor plays an essential role in the pathogenesis of two diseases, it can be concluded that there might be a common root in these two diseases, as well. This review was aimed to highlight the crucial roles of BDNF in the pathogenesis of MetS and NDD and to introduce sole prophylactic or therapeutic applications, BDNF gene therapy and BDFN administration, in controlling MetS and NDD.

Entities: Chemical Disease Gene

Keywords: BDNF; Depression; Metabolic syndrome; Neurodegenerative diseases; Obesity

Mesh：

Substances：

Year: 2017 PMID： 28361262 DOI： 10.1007/s11011-017-9997-0

Source DB: PubMed Journal: Metab Brain Dis ISSN： 0885-7490 Impact factor: 3.584

63 in total

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Journal: Front Cell Neurosci Date: 2015-03-09 Impact factor: 5.505

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Journal: Int J Med Sci Date: 2016-01-01 Impact factor: 3.738

10. Association between obesity and the brain-derived neurotrophic factor gene polymorphism Val66Met in individuals with bipolar disorder in Mexican population.

Authors: Mirna Edith Morales-Marín; Alma Delia Genis-Mendoza; Carlos Alfonso Tovilla-Zarate; Nuria Lanzagorta; Michael Escamilla; Humberto Nicolini
Journal: Neuropsychiatr Dis Treat Date: 2016-07-25 Impact factor: 2.570

26 in total

1. Role of glucocorticoid receptor phosphorylation-mediated synaptic plasticity in anxiogenic and depressive behaviors induced by monosodium glutamate.

Authors: Wen Zhu; Feng Yang; Xiaofang Cai; Wen Zhang; Jingsi Zhang; Min Cai; Xiangting Li; Jun Xiang; Dingfang Cai
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2020-05-22 Impact factor: 3.000

2. Association of BDNF rs11030104 SNP and serum lipid levels in two Chinese ethnic groups.

Authors: Ling Pan; Man-Qiu Mo; Liu Miao; Qing-Hui Zhang; Shuo Yang; Hui Gao; Feng Huang; Shang-Ling Pan; Rui-Xing Yin
Journal: Int J Clin Exp Pathol Date: 2018-03-01

3. Reduced salivary amylase activity in metabolic syndrome patients with obesity could be improved by treatment with a dipeptidyl peptidase IV inhibitor.

Authors: Jitjiroj Ittichaicharoen; Arintaya Phrommintikul; Nipon Chattipakorn; Siriporn Chattipakorn
Journal: Clin Oral Investig Date: 2018-03-08 Impact factor: 3.573

4. Single-Arm 8-Week Ad Libitum Self-Prepared Paleo Diet Reduces Cardiometabolic Disease Risk Factors in Overweight Adults.

Authors: Melissa M Markofski; Kristofer Jennings; Chad Dolan; Natalie A Davies; Emily C LaVoy; Edward J Ryan; Andres E Carrillo
Journal: Am J Lifestyle Med Date: 2019-08-02

5. Predicted gene expression in ancestrally diverse populations leads to discovery of susceptibility loci for lifestyle and cardiometabolic traits.

Authors: Heather M Highland; Genevieve L Wojcik; Mariaelisa Graff; Katherine K Nishimura; Chani J Hodonsky; Antoine R Baldassari; Alanna C Cote; Iona Cheng; Christopher R Gignoux; Ran Tao; Yuqing Li; Eric Boerwinkle; Myriam Fornage; Jeffrey Haessler; Lucia A Hindorff; Yao Hu; Anne E Justice; Bridget M Lin; Danyu Lin; Daniel O Stram; Christopher A Haiman; Charles Kooperberg; Loic Le Marchand; Tara C Matise; Eimear E Kenny; Christopher S Carlson; Eli A Stahl; Christy L Avery; Kari E North; Jose Luis Ambite; Steven Buyske; Ruth J Loos; Ulrike Peters; Kristin L Young; Stephanie A Bien; Laura M Huckins
Journal: Am J Hum Genet Date: 2022-03-08 Impact factor: 11.043

6. A high-fat diet induced NMRI mouse model of metabolic syndrome: focus on brain-derived neurotrophic factor (BDNF).

Authors: Isaac Karimi; Shima Motamedi; Fatemeh Ranjbar
Journal: Metab Brain Dis Date: 2018-06-25 Impact factor: 3.584

Review 7. Neural tone and cardio-renal outcomes in patients with type 2 diabetes mellitus: a review of the literature with a focus on SGLT2 inhibitors.

Authors: Mouhamed Nashawi; Omar Sheikh; Ayman Battisha; Abdullah Ghali; Robert Chilton
Journal: Heart Fail Rev Date: 2020-11-09 Impact factor: 4.214