PURPOSE: Since cytoplasmic pitting is a morphological phenomenon discussed controversially, this study was set up in order to assess the actual influence of cytoplasmic pitting on treatment outcome. METHODS: Four hundred and one patients undergoing 484 consecutive treatment cycles were evaluated retrospectively in order to assess the actual influence of pitting on treatment outcome. RESULTS: Pitting was found to be reduced in single culture as compared to group culture (p < 0.01). No correlation of cytoplasmic texture with rates of implantation and pregnancy could be observed, but a significantly higher proportion (p < 0.05) of gestational sacs vanished in the group with exclusive transfer of pitted embryos compared to the unaffected group. Obstetric and perinatal outcome was not affected. CONCLUSIONS: It is possible that culture conditions favor cytoplasmic pitting, a morphological phenomenon which, in the extreme case, may result in early loss of gestation sacs.
PURPOSE: Since cytoplasmic pitting is a morphological phenomenon discussed controversially, this study was set up in order to assess the actual influence of cytoplasmic pitting on treatment outcome. METHODS: Four hundred and one patients undergoing 484 consecutive treatment cycles were evaluated retrospectively in order to assess the actual influence of pitting on treatment outcome. RESULTS: Pitting was found to be reduced in single culture as compared to group culture (p < 0.01). No correlation of cytoplasmic texture with rates of implantation and pregnancy could be observed, but a significantly higher proportion (p < 0.05) of gestational sacs vanished in the group with exclusive transfer of pitted embryos compared to the unaffected group. Obstetric and perinatal outcome was not affected. CONCLUSIONS: It is possible that culture conditions favor cytoplasmic pitting, a morphological phenomenon which, in the extreme case, may result in early loss of gestation sacs.
Authors: E Van Royen; K Mangelschots; D De Neubourg; M Valkenburg; M Van de Meerssche; G Ryckaert; W Eestermans; J Gerris Journal: Hum Reprod Date: 1999-09 Impact factor: 6.918
Authors: Simon Cooke; Patrick Quinn; Lee Kime; Cheryl Ayres; John P P Tyler; Geoff L Driscoll Journal: Fertil Steril Date: 2002-12 Impact factor: 7.329
Authors: Amin A Milki; Mary D Hinckley; Janice Gebhardt; Daniel Dasig; Lynn M Westphal; Barry Behr Journal: Fertil Steril Date: 2002-06 Impact factor: 7.329
Authors: R Campo; M M Binda; G Van Kerkhoven; V Frederickx; A Serneels; P Roziers; A S Lopes; S Gordts; P Puttemans; S Gordts Journal: Facts Views Vis Obgyn Date: 2010