Literature DB >> 16009547

Have we found the tip link, transduction channel, and gating spring of the hair cell?

Peter G Gillespie1, Rachel A Dumont, Bechara Kachar.   

Abstract

Recent reports have offered candidates for key components of the apparatus used for mechanotransduction in hair cells. TRPA1 and cadherin 23 have been proposed to be the transduction channel and component of the tip link, respectively; moreover, ankyrin repeats in TRPA1 have been proposed to be the gating spring. Although these are excellent candidates for the three components, definitive experiments supporting each identification have yet to be performed.

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Year:  2005        PMID: 16009547     DOI: 10.1016/j.conb.2005.06.007

Source DB:  PubMed          Journal:  Curr Opin Neurobiol        ISSN: 0959-4388            Impact factor:   6.627


  22 in total

Review 1.  Feeling the pressure in mammalian somatosensation.

Authors:  Ellen A Lumpkin; Diana M Bautista
Journal:  Curr Opin Neurobiol       Date:  2005-08       Impact factor: 6.627

Review 2.  Mechano-electrical transduction: new insights into old ideas.

Authors:  A J Ricci; B Kachar; J Gale; S M Van Netten
Journal:  J Membr Biol       Date:  2006-05-25       Impact factor: 1.843

Review 3.  Studying inner ear protein-protein interactions using FRET and FLIM.

Authors:  Richard Hallworth; Benjamin Currall; Michael G Nichols; Xudong Wu; Jian Zuo
Journal:  Brain Res       Date:  2006-04-13       Impact factor: 3.252

4.  Mechanical properties and consequences of stereocilia and extracellular links in vestibular hair bundles.

Authors:  Jong-Hoon Nam; John R Cotton; Ellengene H Peterson; Wally Grant
Journal:  Biophys J       Date:  2006-01-20       Impact factor: 4.033

Review 5.  Repeat-protein folding: new insights into origins of cooperativity, stability, and topology.

Authors:  Ellen Kloss; Naomi Courtemanche; Doug Barrick
Journal:  Arch Biochem Biophys       Date:  2007-09-15       Impact factor: 4.013

Review 6.  Molecular evolution of the vertebrate mechanosensory cell and ear.

Authors:  Bernd Fritzsch; Kirk W Beisel; Sarah Pauley; Garrett Soukup
Journal:  Int J Dev Biol       Date:  2007       Impact factor: 2.203

Review 7.  The micromachinery of mechanotransduction in hair cells.

Authors:  Melissa A Vollrath; Kelvin Y Kwan; David P Corey
Journal:  Annu Rev Neurosci       Date:  2007       Impact factor: 12.449

Review 8.  A mechanism for active hearing.

Authors:  Tianying Ren; Peter G Gillespie
Journal:  Curr Opin Neurobiol       Date:  2007-08-17       Impact factor: 6.627

9.  Pairwise coupling of hair cell transducer channels links auditory sensitivity and dynamic range.

Authors:  Sietse M van Netten; Cécil J W Meulenberg; George W T Lennan; Corné J Kros
Journal:  Pflugers Arch       Date:  2008-12-02       Impact factor: 3.657

10.  Fast adaptation in vestibular hair cells requires myosin-1c activity.

Authors:  Eric A Stauffer; John D Scarborough; Moritoshi Hirono; Emilie D Miller; Kavita Shah; John A Mercer; Jeffrey R Holt; Peter G Gillespie
Journal:  Neuron       Date:  2005-08-18       Impact factor: 17.173

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