| Literature DB >> 15980391 |
Anne-Marie Le Ray1, Hélène Gautier, Marie-Katel Laty, Guy Daculsi, Christian Merle, Cédric Jacqueline, Antoine Hamel, Jocelyne Caillon.
Abstract
Treatment of methicillin-resistant Staphylococcus aureus osteomyelitis requires a prolonged antibiotic therapy with vancomycin. Because of its weak diffusion, the in situ implantation of vancomycin could be interesting. The activity of vancomycin encapsulated in microparticles was evaluated in vitro and in vivo on rabbit osteomyelitis and showed a good activity compared to intravenous administration.Entities:
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Year: 2005 PMID: 15980391 PMCID: PMC1168678 DOI: 10.1128/AAC.49.7.3025-3027.2005
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191