Literature DB >> 15980378

Mutagenesis analysis of a conserved region involved in acetyl coenzyme A binding in the aminoglycoside 6'-N-acetyltransferase type Ib encoded by plasmid pJHCMW1.

Atousa Pourreza1, Mavee Witherspoon, Jessica Fox, Jason Newmark, Duyen Bui, Marcelo E Tolmasky.   

Abstract

Alanine scanning of motif A in the pJHCMW1-encoded aminoglycoside 6'-N-acetyltransferase type Ib identified amino acids important for the ability of the enzyme to confer wild-type levels of resistance to kanamycin and amikacin. The replacement of two amino acids, D117 or L120, with alanine residues resulted in complete loss of the resistance phenotype.

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Year:  2005        PMID： 15980378      PMCID： PMC1168681          DOI： 10.1128/AAC.49.7.2979-2982.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  23 in total

1.  Kinetic and mutagenic characterization of the chromosomally encoded Salmonella enterica AAC(6')-Iy aminoglycoside N-acetyltransferase.

Authors:  S Magnet; T Lambert; P Courvalin; J S Blanchard
Journal:  Biochemistry       Date:  2001-03-27       Impact factor: 3.162

2.  Determining the limits of the evolutionary potential of an antibiotic resistance gene.

Authors:  Stephen J Salipante; Barry G Hall
Journal:  Mol Biol Evol       Date:  2003-04-02       Impact factor: 16.240

3.  Sequencing and expression of aadA, bla, and tnpR from the multiresistance transposon Tn1331.

Authors:  M E Tolmasky
Journal:  Plasmid       Date:  1990-11       Impact factor: 3.466

4.  Comparison of super-secondary structures in proteins.

Authors:  S T Rao; M G Rossmann
Journal:  J Mol Biol       Date:  1973-05-15       Impact factor: 5.469

Review 5.  GCN5-related N-acetyltransferases: a structural overview.

Authors:  F Dyda; D C Klein; A B Hickman
Journal:  Annu Rev Biophys Biomol Struct       Date:  2000

6.  X-ray structure of the AAC(6')-Ii antibiotic resistance enzyme at 1.8 A resolution; examination of oligomeric arrangements in GNAT superfamily members.

Authors:  David L Burk; Navleen Ghuman; Leanne E Wybenga-Groot; Albert M Berghuis
Journal:  Protein Sci       Date:  2003-03       Impact factor: 6.725

7.  Molecular mechanism of the enterococcal aminoglycoside 6'-N-acetyltransferase': role of GNAT-conserved residues in the chemistry of antibiotic inactivation.

Authors:  Kari-ann Draker; Gerard D Wright
Journal:  Biochemistry       Date:  2004-01-20       Impact factor: 3.162

8.  The molecular basis of the expansive substrate specificity of the antibiotic resistance enzyme aminoglycoside acetyltransferase-6'-aminoglycoside phosphotransferase-2". The role of ASP-99 as an active site base important for acetyl transfer.

Authors:  David D Boehr; Stephen I Jenkins; Gerard D Wright
Journal:  J Biol Chem       Date:  2003-02-03       Impact factor: 5.157

9.  Characterization of two aminoglycoside-(3)-N-acetyltransferase genes and assay as epidemiological probes.

Authors:  F Javier Terán; M Alvarez; J E Suárez; M C Mendoza
Journal:  J Antimicrob Chemother       Date:  1991-09       Impact factor: 5.790

10.  Complete nucleotide sequence of Klebsiella pneumoniae multiresistance plasmid pJHCMW1.

Authors:  Renee Sarno; Glen McGillivary; David J Sherratt; Luis A Actis; Marcelo E Tolmasky
Journal:  Antimicrob Agents Chemother       Date:  2002-11       Impact factor: 5.191
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  11 in total

1.  Vibrio cholerae InV117, a class 1 integron harboring aac(6')-Ib and blaCTX-M-2, is linked to transposition genes.

Authors:  Alfonso J C Soler Bistué; Fernando A Martín; Alejandro Petroni; Diego Faccone; Marcelo Galas; Marcelo E Tolmasky; Angeles Zorreguieta
Journal:  Antimicrob Agents Chemother       Date:  2006-05       Impact factor: 5.191

2.  Understanding and overcoming aminoglycoside resistance caused by N-6'-acetyltransferase.

Authors:  Kenward Vong; Karine Auclair
Journal:  Medchemcomm       Date:  2012-04-01       Impact factor: 3.597

Review 3.  Aminoglycoside modifying enzymes.

Authors:  Maria S Ramirez; Marcelo E Tolmasky
Journal:  Drug Resist Updat       Date:  2010-09-15       Impact factor: 18.500

4.  Identification of an Inhibitor of the Aminoglycoside 6'-N-Acetyltransferase type Ib [AAC(6')-Ib] by Glide Molecular Docking.

Authors:  Kevin Chiem; Saumya Jani; Brooke Fuentes; David L Lin; Madeline E Rasche; Marcelo E Tolmasky
Journal:  Medchemcomm       Date:  2015-11-03       Impact factor: 3.597

5.  Mechanistic and structural analysis of aminoglycoside N-acetyltransferase AAC(6')-Ib and its bifunctional, fluoroquinolone-active AAC(6')-Ib-cr variant.

Authors:  Matthew W Vetting; Chi Hye Park; Subray S Hegde; George A Jacoby; David C Hooper; John S Blanchard
Journal:  Biochemistry       Date:  2008-08-19       Impact factor: 3.162

6.  Novel function of N-acetyltransferase for microtubule stability and JNK signaling in Drosophila organ development.

Authors:  Jung-Wan Mok; Kwang-Wook Choi
Journal:  Proc Natl Acad Sci U S A       Date:  2021-01-26       Impact factor: 12.779

Review 7.  Amikacin: Uses, Resistance, and Prospects for Inhibition.

Authors:  Maria S Ramirez; Marcelo E Tolmasky
Journal:  Molecules       Date:  2017-12-19       Impact factor: 4.411

8.  Small Klebsiella pneumoniae Plasmids: Neglected Contributors to Antibiotic Resistance.

Authors:  Maria S Ramirez; Andrés Iriarte; Rodrigo Reyes-Lamothe; David J Sherratt; Marcelo E Tolmasky
Journal:  Front Microbiol       Date:  2019-09-20       Impact factor: 5.640

9.  Rise and dissemination of aminoglycoside resistance: the aac(6')-Ib paradigm.

Authors:  María S Ramirez; Nikolas Nikolaidis; Marcelo E Tolmasky
Journal:  Front Microbiol       Date:  2013-05-17       Impact factor: 5.640

Review 10.  Structure and Functional Diversity of GCN5-Related N-Acetyltransferases (GNAT).

Authors:  Abu Iftiaf Md Salah Ud-Din; Alexandra Tikhomirova; Anna Roujeinikova
Journal:  Int J Mol Sci       Date:  2016-06-28       Impact factor: 5.923
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