| Literature DB >> 15967722 |
Beiyu Liu1, Yanan Liu, Shawn A Motyka, Eddy E C Agbo, Paul T Englund.
Abstract
Kinetoplastid protozoa such as trypanosomes and Leishmania are important because they cause human disease. These parasites are named after one of their most unusual features, a mitochondrial DNA known as kinetoplast DNA (kDNA). Unlike all other DNA in nature, kDNA comprises a giant network of interlocked DNA rings with a topology resembling that of medieval chain mail. The replication of the kDNA network is more complex than previously thought, and the discovery of new proteins involved in this process is currently the best approach for illuminating the replication mechanism.Entities:
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Year: 2005 PMID： 15967722 DOI： 10.1016/j.pt.2005.06.008
Source DB: PubMed Journal: Trends Parasitol ISSN： 1471-4922