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Literature DB >> 15967504

Synthesis, characterization and biological activity of triorganotin 2-phenyl-1,2,3-triazole-4-carboxylates.

Laijin Tian¹, Yuxi Sun, Huijun Li, Xiaoliang Zheng, Yuanzheng Cheng, Xueli Liu, Bochu Qian.

Abstract

The triorganotin 2-phenyl-1,2,3-triazole-4-carboxylates, 2-PhC2N3CO2SnR3 (R=C6H5, 1; c-C6H11, 2; C6H5C(CH3)2CH2, 3), have been prepared and characterized by means of elemental analysis, IR and NMR (1H, 13C and 119Sn) spectroscopy. The crystal structures of 1 and 3 have been determined. Compound 1 is polymeric in nature with a trigonal bipyramidal configuration, and compound 3 shows a tetrahedral geometry. Bioassay results have shown that these compounds have good antibacterial and antitumor activity. The activity against three human tumor cell lines (HeLa, CoLo205 and MCF-7) decreased in the order 1>2>3.

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Year: 2005 PMID： 15967504 DOI： 10.1016/j.jinorgbio.2005.05.006

Source DB: PubMed Journal: J Inorg Biochem ISSN： 0162-0134 Impact factor: 4.155

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Cited

19 in total

1. Cytotoxic effects of two organotin compounds and their mode of inflicting cell death on four mammalian cancer cells.

Authors: Armando Varela-Ramirez; Margaret Costanzo; Yazmin P Carrasco; Keith H Pannell; Renato J Aguilera
Journal: Cell Biol Toxicol Date: 2010-10-31 Impact factor: 6.691

2. α-Azido ketones. Part 7: synthesis of 1,4-disubstituted triazoles by the "click" reaction of various terminal acetylenes with phenacyl azides or α-azidobenzo(hetera)cyclanones.

Authors: Krisztina Kónya; Szabolcs Fekete; Anita Abrahám; Tamás Patonay
Journal: Mol Divers Date: 2012-02-04 Impact factor: 2.943

3. Design, synthesis, in vitro cytotoxic activity evaluation, and apoptosis-induction study of new 9(10H)-acridinone-1,2,3-triazoles.

Authors: Maryam Mohammadi-Khanaposhtani; Maliheh Safavi; Reyhaneh Sabourian; Mohammad Mahdavi; Mahboobeh Pordeli; Mina Saeedi; Sussan Kabudanian Ardestani; Alireza Foroumadi; Abbas Shafiee; Tahmineh Akbarzadeh
Journal: Mol Divers Date: 2015-07-14 Impact factor: 2.943

Synthesis, characterization and biological activity of triorganotin 2-phenyl-1,2,3-triazole-4-carboxylates.

1. Cytotoxic effects of two organotin compounds and their mode of inflicting cell death on four mammalian cancer cells.

2. α-Azido ketones. Part 7: synthesis of 1,4-disubstituted triazoles by the "click" reaction of various terminal acetylenes with phenacyl azides or α-azidobenzo(hetera)cyclanones.

3. Design, synthesis, in vitro cytotoxic activity evaluation, and apoptosis-induction study of new 9(10H)-acridinone-1,2,3-triazoles.

4. Chlorido(dimethyl sulfoxide-κO)triphenyl-tin(IV).

5. [3-(Dimethyl-amino)benzoato]triphenyl-tin(IV).

6. 5-Methyl-1-phenyl-1H-1,2,3-triazole-4-carboxylic acid.

7. 1-Benzyl-5-methyl-1H-1,2,3-triazole-4-carboxylic acid monohydrate.

8. 5-Methyl-1-(3-nitro-benz-yl)-1H-1,2,3-triazole-4-carboxylic acid monohydrate.

9. 2-(4-Eth-oxy-carbon-yl-5-methyl-1H-1,2,3-triazol-1-yl)acetic acid mono-hydrate.

10. Bis(benzyl phenyl sulfoxide-κO)dichloridodiphenyl-tin(IV).