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Literature DB >> 1596084

Corticotropin-releasing hormone-induced seizures in infant rats originate in the amygdala.

T Z Baram¹, E Hirsch, O C Snead, L Schultz.

Abstract

The neuroanatomical substrate of seizures induced by picomolar amounts of corticotropin-releasing hormone in infant rats was investigated. Electrographic and behavioral phenomena were monitored in 42 rat pups aged 5 to 22 days. Rat pups carried bipolar electrodes implanted in subcortical limbic structures, as well as cortical electrodes and intracerebroventricular cannulae. The administration of corticotropin-releasing hormone produced age-specific seizures within minutes, which correlated with rhythmic amygdala discharges. Paroxysmal hippocampal and cortical discharges developed subsequently in some rats. Corticotropin-releasing hormone-induced electrographic and behavioral seizures originate in the amygdala.

Entities: Disease Gene Species

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Year: 1992 PMID： 1596084 PMCID： PMC3153947 DOI： 10.1002/ana.410310505

Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422

27 in total

1. Bicuculline induced seizures in infant rats: ontogeny of behavioral and electrocortical phenomena.

Authors: T Z Baram; O C Snead
Journal: Brain Res Dev Brain Res Date: 1990-12-15

2. Diurnal variations in the content of preprocorticotropin-releasing hormone messenger ribonucleic acids in the hypothalamic paraventricular nucleus of rats of both sexes as measured by in situ hybridization.

Authors: A G Watts; L W Swanson
Journal: Endocrinology Date: 1989-09 Impact factor: 4.736

3. The ontogeny of brain receptors for corticotropin-releasing factor and the development of their functional association with adenylate cyclase.

Authors: T R Insel; G Battaglia; D W Fairbanks; E B De Souza
Journal: J Neurosci Date: 1988-11 Impact factor: 6.167

4. Corticotropin-releasing factor receptors are widely distributed within the rat central nervous system: an autoradiographic study.

Authors: E B De Souza; T R Insel; M H Perrin; J Rivier; W W Vale; M J Kuhar
Journal: J Neurosci Date: 1985-12 Impact factor: 6.167

5. Ontogeny of corticotropin releasing hormone gene expression in rat hypothalamus--comparison with somatostatin.

Authors: T Z Baram; S P Lerner
Journal: Int J Dev Neurosci Date: 1991 Impact factor: 2.457

6. Corticotropin-releasing factor activates noradrenergic neurons of the locus coeruleus.

Authors: R J Valentino; S L Foote; G Aston-Jones
Journal: Brain Res Date: 1983-07-04 Impact factor: 3.252

7. Diurnal variations in electroconvulsive shock-induced seizures: involvement of endogenous opioids.

Authors: A Oliverio; C Castellano; S Puglisi-Allegra; P Renzi
Journal: Neurosci Lett Date: 1985-06-24 Impact factor: 3.046

8. Corticotropin releasing factor produces increases in brain excitability and convulsive seizures in rats.

Authors: C L Ehlers; S J Henriksen; M Wang; J Rivier; W Vale; F E Bloom
Journal: Brain Res Date: 1983-11-14 Impact factor: 3.252

9. Distribution of corticotropin-releasing factor in rat brain.

Authors: M Palkovits; M J Brownstein; W Vale
Journal: Fed Proc Date: 1985-01

10. Effect of D-tubocurarine immobilization on the resting electroencephalogram in the rat.

Authors: J Pokorný; J Sterc
Journal: Electroencephalogr Clin Neurophysiol Date: 1980-02

54 in total

1. Gender difference in acquired seizure susceptibility in adult rats after early complex febrile seizures.

Authors: Yun-Jian Dai; Zheng-Hao Xu; Bo Feng; Ceng-Lin Xu; Hua-Wei Zhao; Deng-Chang Wu; Wei-Wei Hu; Zhong Chen
Journal: Neurosci Bull Date: 2014-11-13 Impact factor: 5.203

Review 2. Exposure to prenatal psychobiological stress exerts programming influences on the mother and her fetus.

Authors: Curt A Sandman; Elysia P Davis; Claudia Buss; Laura M Glynn
Journal: Neuroendocrinology Date: 2011-04-15 Impact factor: 4.914

3. Selective death of hippocampal CA3 pyramidal cells with mossy fiber afferents after CRH-induced status epilepticus in infant rats.

Authors: C E Ribak; T Z Baram
Journal: Brain Res Dev Brain Res Date: 1996-02-26

Corticotropin-releasing hormone-induced seizures in infant rats originate in the amygdala.

1. Bicuculline induced seizures in infant rats: ontogeny of behavioral and electrocortical phenomena.

2. Diurnal variations in the content of preprocorticotropin-releasing hormone messenger ribonucleic acids in the hypothalamic paraventricular nucleus of rats of both sexes as measured by in situ hybridization.

3. The ontogeny of brain receptors for corticotropin-releasing factor and the development of their functional association with adenylate cyclase.

4. Corticotropin-releasing factor receptors are widely distributed within the rat central nervous system: an autoradiographic study.

5. Ontogeny of corticotropin releasing hormone gene expression in rat hypothalamus--comparison with somatostatin.

6. Corticotropin-releasing factor activates noradrenergic neurons of the locus coeruleus.

7. Diurnal variations in electroconvulsive shock-induced seizures: involvement of endogenous opioids.

8. Corticotropin releasing factor produces increases in brain excitability and convulsive seizures in rats.

9. Distribution of corticotropin-releasing factor in rat brain.

10. Effect of D-tubocurarine immobilization on the resting electroencephalogram in the rat.

1. Gender difference in acquired seizure susceptibility in adult rats after early complex febrile seizures.

Review 2. Exposure to prenatal psychobiological stress exerts programming influences on the mother and her fetus.

3. Selective death of hippocampal CA3 pyramidal cells with mossy fiber afferents after CRH-induced status epilepticus in infant rats.

4. Corticotrophin-ACTH in Comparison to Prednisolone in West Syndrome - A Randomized Study.

Review 5. Neuropeptide-mediated excitability: a key triggering mechanism for seizure generation in the developing brain.

6. Peptide-induced infant status epilepticus causes neuronal death and synaptic reorganization.

Review 7. Febrile seizures and mechanisms of epileptogenesis: insights from an animal model.

8. A review of adversity, the amygdala and the hippocampus: a consideration of developmental timing.

9. Developmental profile of messenger RNA for the corticotropin-releasing hormone receptor in the rat limbic system.

10. The brain, seizures and epilepsy throughout life: understanding a moving target.