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Literature DB >> 2073726

Bicuculline induced seizures in infant rats: ontogeny of behavioral and electrocortical phenomena.

Abstract

The effects of bicuculline, a gamma-aminobutyric acid (GABA) antagonist, were investigated in 258 immature rats between the third and 22nd postnatal days. Behavioral and electrocorticographic events were correlated. Bicuculline induced both behavioral and electrographic seizures as early as the third postnatal day, an age when the CD50 for bicuculline was lowest, and therefore the sensitivity to it was the greatest. Bicuculline may thus be a suitable convulsant for epilepsy studies involving rats during the first postnatal week.

Entities: Chemical Disease Species

Mesh：

Substances：
Bicuculline

Year: 1990 PMID： 2073726 PMCID： PMC3139479 DOI： 10.1016/0165-3806(90)90055-4

Source DB: PubMed Journal: Brain Res Dev Brain Res ISSN： 0165-3806

21 in total

Bicuculline induced seizures in infant rats: ontogeny of behavioral and electrocortical phenomena.

Review 1. Aspects of epileptogenesis: maturation of neuronal circuits.

2. Effects of bicuculline-induced seizures on benzodiazepine and adenosine receptors in developing rat brain.

3. The developing animal as a model.

4. Prenatal ontogeny of the GABAergic system in the rat brain: an immunocytochemical study.

5. Development of a "blood-brain barrier" to methadone in the newborn rat.

6. Variation in threshold and pattern of electroshock-induced seizures in rats depending on site of stimulation.

7. Time course of the anticonvulsant action of clonazepam during ontogenesis in the rat.

8. Nigral muscimol infusions facilitate the development of seizures in immature rats.

9. The susceptibility of rats to pilocarpine-induced seizures is age-dependent.

10. gamma-Aminobutyric acid opens Cl-channels in cultured astrocytes.

1. Corticotropin-releasing hormone-induced seizures in infant rats originate in the amygdala.

2. GABA depolarizes immature neurons and inhibits network activity in the neonatal neocortex in vivo.

3. Puritan's View of the "Ménage à Trois".

4. Functional GABAergic synaptic connection in neonatal mouse barrel cortex.

Review 5. Depolarizing GABA and developmental epilepsies.

6. HIV gp120 upregulates tonic inhibition through α5-containing GABA_ARs.

7. The brain, seizures and epilepsy throughout life: understanding a moving target.

Review 8. GABAergic Synchronization in Epilepsy.

Review 9. Searching for new targets for treatment of pediatric epilepsy.

Review 10. Carbon monoxide and hydrogen sulfide: gaseous messengers in cerebrovascular circulation.