Literature DB >> 15932334

Improved solution- and solid-phase preparation of hydroxamic acids from esters.

Chih Y Ho1, Eric Strobel, Janet Ralbovsky, Robert A Galemmo.   

Abstract

The addition of small amounts of solid KCN to solution and solid-phase esters in THF/MeOH/50% aqueous NH2OH increases the efficiency of their transformation to the corresponding hydroxamic acids.

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Year:  2005        PMID： 15932334     DOI： 10.1021/jo050036f

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  11 in total

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3.  Synthesis, characterization and development of a high-throughput methodology for the discovery of botulinum neurotoxin a inhibitors.

Authors:  Grant E Boldt; Jack P Kennedy; Mark S Hixon; Laura A McAllister; Joseph T Barbieri; Saul Tzipori; Kim D Janda
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4.  Radionuclide labeling and evaluation of candidate radioligands for PET imaging of histone deacetylase in the brain.

Authors:  Young Jun Seo; Lisa Muench; Alicia Reid; Jinzhu Chen; Yeona Kang; Jacob M Hooker; Nora D Volkow; Joanna S Fowler; Sung Won Kim
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5.  Synthesis and structure-activity relationships of second-generation hydroxamate botulinum neurotoxin A protease inhibitors.

Authors:  Katerina Capková; Yoshiyuki Yoneda; Tobin J Dickerson; Kim D Janda
Journal:  Bioorg Med Chem Lett       Date:  2007-10-09       Impact factor: 2.823

6.  Synthesis/biological evaluation of hydroxamic acids and their prodrugs as inhibitors for Botulinum neurotoxin A light chain.

Authors:  Hajime Seki; Sabine Pellett; Peter Silhár; G Neil Stowe; Beatriz Blanco; Matthew A Lardy; Eric A Johnson; Kim D Janda
Journal:  Bioorg Med Chem       Date:  2013-12-08       Impact factor: 3.641

7.  Convenient Synthesis of a Library of Discrete Hydroxamic Acids Using the Hydroxythiophenol (Marshall) Resin.

Authors:  Jinil Choi; Jewn Giew Park; Yuan-Ping Pang
Journal:  Tetrahedron Lett       Date:  2008-02-11       Impact factor: 2.415

8.  High-density integration of carbon nanotubes via chemical self-assembly.

Authors:  Hongsik Park; Ali Afzali; Shu-Jen Han; George S Tulevski; Aaron D Franklin; Jerry Tersoff; James B Hannon; Wilfried Haensch
Journal:  Nat Nanotechnol       Date:  2012-10-28       Impact factor: 39.213

9.  Potent new small-molecule inhibitor of botulinum neurotoxin serotype A endopeptidase developed by synthesis-based computer-aided molecular design.

Authors:  Yuan-Ping Pang; Anuradha Vummenthala; Rajesh K Mishra; Jewn Giew Park; Shaohua Wang; Jon Davis; Charles B Millard; James J Schmidt
Journal:  PLoS One       Date:  2009-11-10       Impact factor: 3.240

10.  Computer-aided lead optimization: improved small-molecule inhibitor of the zinc endopeptidase of botulinum neurotoxin serotype A.

Authors:  Jing Tang; Jewn Giew Park; Charles B Millard; James J Schmidt; Yuan-Ping Pang
Journal:  PLoS One       Date:  2007-08-22       Impact factor: 3.240
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