Literature DB >> 15925537

Fragonomics: fragment-based drug discovery.

Edward R Zartler1, Michael J Shapiro.   

Abstract

The use of smaller molecules (fragments) in the drug discovery process has led to success in delivering novel leads for many different targets. This process is a highly integrated process, starting from library design to screening and medicinal chemistry. An overview of this process is presented with particular emphasis placed on the NMR aspect of screening.

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Year:  2005        PMID： 15925537     DOI： 10.1016/j.cbpa.2005.05.002

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


  12 in total

1.  Targeting zinc finger domains with small molecules: solution structure and binding studies of the RanBP2-type zinc finger of RBM5.

Authors:  Biancamaria Farina; Roberto Fattorusso; Maurizio Pellecchia
Journal:  Chembiochem       Date:  2011-12-16       Impact factor: 3.164

2.  Fragonomics: the -omics with real impact.

Authors:  Edward R Zartler
Journal:  ACS Med Chem Lett       Date:  2014-08-13       Impact factor: 4.345

3.  The analysis of the market success of FDA approvals by probing top 100 bestselling drugs.

Authors:  Jaroslaw Polanski; Jacek Bogocz; Aleksandra Tkocz
Journal:  J Comput Aided Mol Des       Date:  2016-04-28       Impact factor: 3.686

4.  Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei.

Authors:  Darren W Begley; Robert C Hartley; Douglas R Davies; Thomas E Edwards; Jess T Leonard; Jan Abendroth; Courtney A Burris; Janhavi Bhandari; Peter J Myler; Bart L Staker; Lance J Stewart
Journal:  J Struct Funct Genomics       Date:  2011-02-26

Review 5.  Fragment screening and HIV therapeutics.

Authors:  Joseph D Bauman; Disha Patel; Eddy Arnold
Journal:  Top Curr Chem       Date:  2012

Review 6.  High-Throughput Screening by Nuclear Magnetic Resonance (HTS by NMR) for the Identification of PPIs Antagonists.

Authors:  Bainan Wu; Elisa Barile; Surya K De; Jun Wei; Angela Purves; Maurizio Pellecchia
Journal:  Curr Top Med Chem       Date:  2015       Impact factor: 3.295

Review 7.  Perspectives on NMR in drug discovery: a technique comes of age.

Authors:  Maurizio Pellecchia; Ivano Bertini; David Cowburn; Claudio Dalvit; Ernest Giralt; Wolfgang Jahnke; Thomas L James; Steve W Homans; Horst Kessler; Claudio Luchinat; Bernd Meyer; Hartmut Oschkinat; Jeff Peng; Harald Schwalbe; Gregg Siegal
Journal:  Nat Rev Drug Discov       Date:  2008-09       Impact factor: 84.694

Review 8.  Fragment-based cocktail crystallography by the medical structural genomics of pathogenic protozoa consortium.

Authors:  Christophe L M J Verlinde; Erkang Fan; Sayaka Shibata; Zongsheng Zhang; Zhihua Sun; Wei Deng; Jennifer Ross; Jessica Kim; Liren Xiao; Tracy L Arakaki; Jürgen Bosch; Jonathan M Caruthers; Eric T Larson; Isolde Letrong; Alberto Napuli; Angela Kelly; Natasha Mueller; Frank Zucker; Wesley C Van Voorhis; Frederick S Buckner; Ethan A Merritt; Wim G J Hol
Journal:  Curr Top Med Chem       Date:  2009       Impact factor: 3.295

9.  Rationalizing fragment based drug discovery for BACE1: insights from FB-QSAR, FB-QSSR, multi objective (MO-QSPR) and MIF studies.

Authors:  Prabu Manoharan; R S K Vijayan; Nanda Ghoshal
Journal:  J Comput Aided Mol Des       Date:  2010-08-26       Impact factor: 3.686

Review 10.  NMR-based approaches for the identification and optimization of inhibitors of protein-protein interactions.

Authors:  Elisa Barile; Maurizio Pellecchia
Journal:  Chem Rev       Date:  2014-04-08       Impact factor: 60.622
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