Literature DB >> 25221648

Fragonomics: the -omics with real impact.

Edward R Zartler1.   

Abstract

Fragonomics is the process of using small, relatively simple molecules to generate chemical starting points for hit generation. Fragonomics has come of age and is now one of the major concepts in hit generation. What is its future?

Year:  2014        PMID： 25221648      PMCID： PMC4160759          DOI： 10.1021/ml5003212

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  2 in total

Review 1.  Molecular complexity and its impact on the probability of finding leads for drug discovery.

Authors:  M M Hann; A R Leach; G Harper
Journal:  J Chem Inf Comput Sci       Date:  2001 May-Jun

Review 2.  Fragonomics: fragment-based drug discovery.

Authors:  Edward R Zartler; Michael J Shapiro
Journal:  Curr Opin Chem Biol       Date:  2005-08       Impact factor: 8.822
  2 in total
  5 in total

1.  When Does Chemical Elaboration Induce a Ligand To Change Its Binding Mode?

Authors:  Shipra Malhotra; John Karanicolas
Journal:  J Med Chem       Date:  2016-12-16       Impact factor: 7.446

2.  A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.

Authors:  Cho Yeow Koh; Latha Kallur Siddaramaiah; Ranae M Ranade; Jasmine Nguyen; Tengyue Jian; Zhongsheng Zhang; J Robert Gillespie; Frederick S Buckner; Christophe L M J Verlinde; Erkang Fan; Wim G J Hol
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2015-07-31

3.  Partially Saturated Bicyclic Heteroaromatics as an sp(3) -Enriched Fragment Collection.

Authors:  David G Twigg; Noriyasu Kondo; Sophie L Mitchell; Warren R J D Galloway; Hannah F Sore; Andrew Madin; David R Spring
Journal:  Angew Chem Int Ed Engl       Date:  2016-09-06       Impact factor: 15.336

4.  The potential use of single-particle electron microscopy as a tool for structure-based inhibitor design.

Authors:  S Rawson; M J McPhillie; R M Johnson; C W G Fishwick; S P Muench
Journal:  Acta Crystallogr D Struct Biol       Date:  2017-04-20       Impact factor: 7.652

Review 5.  Recyclization of Maleimides by Binucleophiles as a General Approach for Building Hydrogenated Heterocyclic Systems.

Authors:  Dmitriy Yu Vandyshev; Khidmet S Shikhaliev
Journal:  Molecules       Date:  2022-08-18       Impact factor: 4.927
  5 in total

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