Literature DB >> 15916684

Polymorphisms in cytochrome P450 17A1 and risk of non-Hodgkin lymphoma.

Christine F Skibola1, Tracy Lightfoot, Luz Agana, Alex Smith, Sara Rollinson, Andrew Kao, Peter Adamson, Gareth J Morgan, Martyn T Smith, Eve Roman.   

Abstract

Broad cross-talk exists between the endocrine and immune systems. Estrogen receptor expression in lymphocytes suggests that hormonal modulation may influence lymphoma risk. Analysis of genetic polymorphisms that affect oestrogen production, such as cytochrome P450 17A1 (CYP17A1) -34T>C, may provide insight into oestrogen's role in lymphomagenesis. CYP17A1-34T>C and CYP17A1 IVS2 105A>C polymorphisms were analyzed in a non-Hodgkin lymphoma (NHL) population-based case-control study. The CYP17A1-34CC genotype was positively associated with NHL [odds ratio (OR) = 1.44, 95% confidence interval (CI) 1.02-2.03], particularly diffuse large B-cell lymphoma (OR = 1.76, CI 1.14-2.71). Associations of CYP17A1 polymorphisms with increased risk of NHL suggest a role for oestrogen in lymphomagenesis.

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Year:  2005        PMID： 15916684     DOI： 10.1111/j.1365-2141.2005.05505.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  7 in total

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Authors:  James R Cerhan
Journal:  Best Pract Res Clin Haematol       Date:  2011-05-05       Impact factor: 3.020

2.  Genetic polymorphisms in cytochrome P450s, GSTs, NATs, alcohol consumption and risk of non-Hodgkin lymphoma.

Authors:  Yonghong Li; Tongzhang Zheng; Briseis A Kilfoy; Qing Lan; Theodore Holford; Xuesong Han; Ping Zhao; Min Dai; Brian Leaderer; Nat Rothman; Yawei Zhang
Journal:  Am J Hematol       Date:  2010-03       Impact factor: 10.047

3.  The role of estrogen receptor β in transplacental cancer prevention by indole-3-carbinol.

Authors:  Abby D Benninghoff; David E Williams
Journal:  Cancer Prev Res (Phila)       Date:  2013-02-27

4.  Urinary biomarkers suggest that estrogen-DNA adducts may play a role in the aetiology of non-Hodgkin lymphoma.

Authors:  Nilesh W Gaikwad; Li Yang; Dennis D Weisenburger; Julie Vose; Cheryl Beseler; Eleanor G Rogan; Ercole L Cavalieri
Journal:  Biomarkers       Date:  2009-11       Impact factor: 2.658

5.  Genetic polymorphisms in glutathione S-transferases and cytochrome P450s, tobacco smoking, and risk of non-Hodgkin lymphoma.

Authors:  Briseis A Kilfoy; Tongzhang Zheng; Qing Lan; Xuesong Han; Qin Qin; Nathaniel Rothman; Theodore Holford; Yawei Zhang
Journal:  Am J Hematol       Date:  2009-05       Impact factor: 10.047

Review 6.  Genetic susceptibility to lymphoma.

Authors:  Christine F Skibola; John D Curry; Alexandra Nieters
Journal:  Haematologica       Date:  2007-07       Impact factor: 9.941

7.  Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.

Authors:  Christine F Skibola; Paige M Bracci; Eran Halperin; Alexandra Nieters; Alan Hubbard; Randi A Paynter; Danica R Skibola; Luz Agana; Nikolaus Becker; Patrick Tressler; Matthew S Forrest; Sriram Sankararaman; Lucia Conde; Elizabeth A Holly; Martyn T Smith
Journal:  PLoS One       Date:  2008-06-30       Impact factor: 3.240
  7 in total

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