Literature DB >> 20131310

Genetic polymorphisms in cytochrome P450s, GSTs, NATs, alcohol consumption and risk of non-Hodgkin lymphoma.

Yonghong Li, Tongzhang Zheng, Briseis A Kilfoy, Qing Lan, Theodore Holford, Xuesong Han, Ping Zhao, Min Dai, Brian Leaderer, Nat Rothman, Yawei Zhang.   

Abstract

The aim of this study was to investigate whether genetic polymorphisms in cytochrome P450s (CYPs), glutathione S-transferases (GSTs), and N-acetyltransferases (NATs) genes modify the relationship between alcohol consumption and risk of non-Hodgkin's lymphoma (NHL) in a population-based, case-control study including 1,115 Connecticut women. Although we did not find strong evidence that the genetic polymorphisms modify the relationship between alcohol consumption and risk of NHL, we identified significant interactions for multiple GSTs and NATs and alcohol intake among persons with DLBCL. Our results confer support investigation of the gene-environment interaction in a larger study population of DLBCL.

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Year:  2010        PMID： 20131310      PMCID： PMC2965357          DOI： 10.1002/ajh.21608

Source DB:  PubMed          Journal:  Am J Hematol        ISSN： 0361-8609            Impact factor:   10.047


  29 in total

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