Literature DB >> 19863189

Urinary biomarkers suggest that estrogen-DNA adducts may play a role in the aetiology of non-Hodgkin lymphoma.

Nilesh W Gaikwad1, Li Yang, Dennis D Weisenburger, Julie Vose, Cheryl Beseler, Eleanor G Rogan, Ercole L Cavalieri.   

Abstract

A variety of evidence suggests that estrogens may induce non-Hodgkin lymphoma (NHL). The reaction of catechol estrogen quinones with DNA to form depurinating estrogen-DNA adducts is hypothesized to initiate this process. These adducts are released from DNA, shed from cells into the bloodstream and excreted in urine. The aim of this study was to determine whether or not the depurinating estrogen-DNA adducts might be involved in the aetiology of human NHL. Estrogen metabolites, conjugates and depurinating DNA adducts were identified and quantified in spot urine samples from 15 men with NHL and 30 healthy control men by using ultraperformance liquid chromatography/tandem mass spectrometry. The levels of estrogen-DNA adducts were significantly higher in the men with NHL than in the healthy control men. Thus, formation of estrogen-DNA adducts may play a critical role in the aetiology of NHL, and these adducts could be potential biomarkers of NHL risk.

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Year:  2009        PMID： 19863189      PMCID： PMC4423407          DOI： 10.3109/13547500903121715

Source DB:  PubMed          Journal:  Biomarkers        ISSN： 1354-750X            Impact factor:   2.658


  48 in total

1.  Prior medication use and health history as risk factors for non-Hodgkin's lymphoma: preliminary results from a case-control study in Los Angeles County.

Authors:  L Bernstein; R K Ross
Journal:  Cancer Res       Date:  1992-10-01       Impact factor: 12.701

2.  Causal relationship between non-Hodgkin's lymphoma and exposure to benzene and benzene-containing solvents.

Authors:  Myron A Mehlman
Journal:  Ann N Y Acad Sci       Date:  2006-09       Impact factor: 5.691

3.  The greater reactivity of estradiol-3,4-quinone vs estradiol-2,3-quinone with DNA in the formation of depurinating adducts: implications for tumor-initiating activity.

Authors:  Muhammad Zahid; Ekta Kohli; Muhammad Saeed; Eleanor Rogan; Ercole Cavalieri
Journal:  Chem Res Toxicol       Date:  2006-01       Impact factor: 3.739

4.  Occupational exposure to solvents and the risk of lymphomas.

Authors:  Lucia Miligi; Adele Seniori Costantini; Alessandra Benvenuti; David Kriebel; Vanessa Bolejack; Rosario Tumino; Valerio Ramazzotti; Stefania Rodella; Emanuele Stagnaro; Paolo Crosignani; Dino Amadori; Dario Mirabelli; Letizia Sommani; Isabella Belletti; Loredana Troschel; Luciano Romeo; Giuseppe Miceli; Giulio Andrea Tozzi; Igino Mendico; Paolo Vineis
Journal:  Epidemiology       Date:  2006-09       Impact factor: 4.822

Review 5.  Perspectives in hormonal carcinogenesis: animal models to human disease.

Authors:  J J Li
Journal:  Prog Clin Biol Res       Date:  1996

Review 6.  Benzene and non-Hodgkin's lymphoma.

Authors:  S R O'Connor; P B Farmer; I Lauder
Journal:  J Pathol       Date:  1999-12       Impact factor: 7.996

7.  Imbalance of estrogen homeostasis in kidney and liver of hamsters treated with estradiol: implications for estrogen-induced initiation of renal tumors.

Authors:  E L Cavalieri; S Kumar; R Todorovic; S Higginbotham; A F Badawi; E G Rogan
Journal:  Chem Res Toxicol       Date:  2001-08       Impact factor: 3.739

8.  Catechol estrogen metabolites and conjugates in mammary tumors and hyperplastic tissue from estrogen receptor-alpha knock-out (ERKO)/Wnt-1 mice: implications for initiation of mammary tumors.

Authors:  P Devanesan; R J Santen; W P Bocchinfuso; K S Korach; E G Rogan; E Cavalieri
Journal:  Carcinogenesis       Date:  2001-09       Impact factor: 4.944

9.  Synthesis and structure elucidation of estrogen quinones conjugated with cysteine, N-acetylcysteine, and glutathione.

Authors:  K Cao; D E Stack; R Ramanathan; M L Gross; E G Rogan; E L Cavalieri
Journal:  Chem Res Toxicol       Date:  1998-08       Impact factor: 3.739

10.  Prevention of estrogen-DNA adduct formation in MCF-10F cells by resveratrol.

Authors:  Muhammad Zahid; Nilesh W Gaikwad; Mohamed F Ali; Fang Lu; Muhammad Saeed; Li Yang; Eleanor G Rogan; Ercole L Cavalieri
Journal:  Free Radic Biol Med       Date:  2008-04-08       Impact factor: 7.376
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  15 in total

1.  Mechanism of DNA depurination by carcinogens in relation to cancer initiation.

Authors:  Ercole Cavalieri; Muhammad Saeed; Muhammad Zahid; David Cassada; Daniel Snow; Momcilo Miljkovic; Eleanor Rogan
Journal:  IUBMB Life       Date:  2011-12-09       Impact factor: 3.885

Review 2.  The molecular etiology and prevention of estrogen-initiated cancers: Ockham's Razor: Pluralitas non est ponenda sine necessitate. Plurality should not be posited without necessity.

Authors:  Ercole Cavalieri; Eleanor Rogan
Journal:  Mol Aspects Med       Date:  2013-08-30

3.  Peroxidase-mediated dealkylation of tamoxifen, detected by electrospray ionization-mass spectrometry, and activation to form DNA adducts.

Authors:  Nilesh W Gaikwad; William J Bodell
Journal:  Free Radic Biol Med       Date:  2011-10-18       Impact factor: 7.376

4.  Unbalanced estrogen metabolism in ovarian cancer.

Authors:  Muhammad Zahid; Cheryl L Beseler; James B Hall; Tricia LeVan; Ercole L Cavalieri; Eleanor G Rogan
Journal:  Int J Cancer       Date:  2014-01-25       Impact factor: 7.396

Review 5.  Depurinating estrogen-DNA adducts in the etiology and prevention of breast and other human cancers.

Authors:  Ercole L Cavalieri; Eleanor G Rogan
Journal:  Future Oncol       Date:  2010-01       Impact factor: 3.404

6.  Imbalanced estrogen metabolism in the brain: possible relevance to the etiology of Parkinson's disease.

Authors:  Nilesh W Gaikwad; Daniel Murman; Cheryl L Beseler; Muhammad Zahid; Eleanor G Rogan; Ercole L Cavalieri
Journal:  Biomarkers       Date:  2011-06-21       Impact factor: 2.658

7.  Isotope Dilution nanoLC/ESI+-HRMS3 Quantitation of Urinary N7-(1-Hydroxy-3-buten-2-yl) Guanine Adducts in Humans and Their Use as Biomarkers of Exposure to 1,3-Butadiene.

Authors:  Dewakar Sangaraju; Emily J Boldry; Yesha M Patel; Vernon Walker; Irina Stepanov; Daniel Stram; Dorothy Hatsukami; Natalia Tretyakova
Journal:  Chem Res Toxicol       Date:  2017-01-17       Impact factor: 3.739

Review 8.  Unbalanced metabolism of endogenous estrogens in the etiology and prevention of human cancer.

Authors:  Ercole L Cavalieri; Eleanor G Rogan
Journal:  J Steroid Biochem Mol Biol       Date:  2011-03-21       Impact factor: 4.292

9.  Unbalanced estrogen metabolism in thyroid cancer.

Authors:  Muhammad Zahid; Whitney Goldner; Cheryl L Beseler; Eleanor G Rogan; Ercole L Cavalieri
Journal:  Int J Cancer       Date:  2013-06-14       Impact factor: 7.396

10.  Metabolomic profiling unravels DNA adducts in human breast that are formed from peroxidase mediated activation of estrogens to quinone methides.

Authors:  Nilesh W Gaikwad
Journal:  PLoS One       Date:  2013-06-06       Impact factor: 3.240
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