PURPOSE: To evaluate the efficacy of topical (1%) and systemic itraconazole against common fungi such as Aspergillus and other filamentous fungi that cause mycotic corneal ulcer. METHODS: A prospective randomised, controlled study was done in 54 clinically suspected cases of fungal keratitis of which 44 were culture proven. Half the cases (n=27) with superficial involvement were treated with onlytopical itraconazole (1%) and the other half were treated with both topical and systemic itraconazole. RESULTS: Aspergillus, Penicillium and Fusarium were the most common fungi isolated. The ulcer resolved in 42 eyes (77%) and 12 eyes (23%) did not respond well to treatment. Four of 12 non-responding eyes were caused by Fusarium species. CONCLUSION:Itraconazole, given either topically or systemically, is effective in treating mycotic corneal ulcers.
RCT Entities:
PURPOSE: To evaluate the efficacy of topical (1%) and systemic itraconazole against common fungi such as Aspergillus and other filamentous fungi that cause mycotic corneal ulcer. METHODS: A prospective randomised, controlled study was done in 54 clinically suspected cases of fungal keratitis of which 44 were culture proven. Half the cases (n=27) with superficial involvement were treated with only topical itraconazole (1%) and the other half were treated with both topical and systemic itraconazole. RESULTS: Aspergillus, Penicillium and Fusarium were the most common fungi isolated. The ulcer resolved in 42 eyes (77%) and 12 eyes (23%) did not respond well to treatment. Four of 12 non-responding eyes were caused by Fusarium species. CONCLUSION:Itraconazole, given either topically or systemically, is effective in treating mycotic corneal ulcers.
Authors: Palanisamy Manikandan; János Varga; Sándor Kocsubé; Rajaraman Revathi; Raghavan Anita; Ilona Dóczi; Tibor Mihály Németh; Venkatapathy Narendran; Csaba Vágvölgyi; Madhavan Bhaskar; Chockaiya Manoharan; Robert A Samson; László Kredics Journal: J Med Case Rep Date: 2010-02-24