| Literature DB >> 15885316 |
Anuja Ghorpade1, Leslie Bruch, Yuri Persidsky, Betty Chin, William H C Brown, Kathleen Borgmann, Raisa Persidsky, Li Wu, Spring Holter, Robin Cotter, Jill Faraci, David Heilman, VaKara Meyer, Jane F Potter, Susan Swindells, Howard E Gendelman.
Abstract
Human glia are essential cellular models used for studies of neurodegenerative diseases. Fetal neuroglia are commonly used, as they can be recovered in large quantities and sustained for long periods in culture. However, fetal neuroglia may have limitations in reflecting adult diseases and additionally can pose ethical issues in translating products of abortion for research use. To address these concerns, we developed a rapid autopsy program to procure age- and disease-specific neuroglia from adult brain tissues within hours of death. The challenges in developing this initiative, reflecting experiences from 69 autopsies over 4 years, are presented.Entities:
Mesh：
Year: 2005 PMID： 15885316 DOI： 10.1016/j.jneuroim.2005.01.021
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478