| Literature DB >> 15882632 |
Li-Chun Cheng1, Masoud Tavazoie, Fiona Doetsch.
Abstract
The complexity and cellular diversity of the adult brain arises from the proliferation and differentiation of a small number of stem cells. The intrinsic state of stem cells depends on their spatial and temporal history and affects their responsiveness to extrinsic signals from the microenvironment. Stem cell self-renewal and differentiation along neuronal and glial lineages are defined by the dynamic interplay between transcription, epigenetic control, and posttranscriptional regulators, including microRNAs, whose key role in stem cell biology is just emerging.Mesh：
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Year: 2005 PMID： 15882632 DOI： 10.1016/j.neuron.2005.04.027
Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173