Literature DB >> 15876648

A method and technical equipment for an acute human trial to evaluate retinal implant technology.

Ralf Hornig1, Thomas Laube, Peter Walter, Michaela Velikay-Parel, Norbert Bornfeld, Matthias Feucht, Harun Akguel, Gernot Rössler, Nils Alteheld, Dietmar Lütke Notarp, John Wyatt, Gisbert Richard.   

Abstract

This paper reports on methods and technical equipment to investigate the epiretinal stimulation of the retina in blind human subjects in acute trials. Current is applied to the retina through a thin, flexible microcontact film (microelectrode array) with electrode diameters ranging from 50 to 360 microm. The film is mounted in a custom-designed surgical tool that is hand-held by the surgeon during stimulation. The eventual goal of the work is the development of a chronically implantable retinal prosthesis to restore a useful level of vision to patients who are blind with outer retinal degenerations, specifically retinitis pigmentosa and macular degeneration.

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Year:  2005        PMID: 15876648     DOI: 10.1088/1741-2560/2/1/014

Source DB:  PubMed          Journal:  J Neural Eng        ISSN: 1741-2552            Impact factor:   5.379


  12 in total

Review 1.  [Status of the subretinal implant project. An overview].

Authors:  F Gekeler; E Zrenner
Journal:  Ophthalmologe       Date:  2005-10       Impact factor: 1.059

2.  Axonal sodium-channel bands shape the response to electric stimulation in retinal ganglion cells.

Authors:  Shelley I Fried; Aaron C W Lasker; Neal J Desai; Donald K Eddington; Joseph F Rizzo
Journal:  J Neurophysiol       Date:  2009-02-04       Impact factor: 2.714

3.  Intraorbital optic nerve stimulation with penetrating electrodes: in vivo electrophysiology study in rabbits.

Authors:  Liming Li; Pengjia Cao; Mingjie Sun; Xinyu Chai; Kaijie Wu; Xun Xu; Xiaoxin Li; Qiushi Ren
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2008-11-07       Impact factor: 3.117

4.  Electrically-evoked Neural Activities of rd1 Mice Retinal Ganglion Cells by Repetitive Pulse Stimulation.

Authors:  Sang Baek Ryu; Jang Hee Ye; Jong Seung Lee; Yong Sook Goo; Chi Hyun Kim; Kyung Hwan Kim
Journal:  Korean J Physiol Pharmacol       Date:  2009-12-31       Impact factor: 2.016

Review 5.  Progress toward effective treatments for human photoreceptor degenerations.

Authors:  Edwin M Stone
Journal:  Curr Opin Genet Dev       Date:  2009-05-04       Impact factor: 5.578

6.  Subretinal electronic chips allow blind patients to read letters and combine them to words.

Authors:  Eberhart Zrenner; Karl Ulrich Bartz-Schmidt; Heval Benav; Dorothea Besch; Anna Bruckmann; Veit-Peter Gabel; Florian Gekeler; Udo Greppmaier; Alex Harscher; Steffen Kibbel; Johannes Koch; Akos Kusnyerik; Tobias Peters; Katarina Stingl; Helmut Sachs; Alfred Stett; Peter Szurman; Barbara Wilhelm; Robert Wilke
Journal:  Proc Biol Sci       Date:  2010-11-03       Impact factor: 5.349

7.  Implantable CMOS Biomedical Devices.

Authors:  Jun Ohta; Takashi Tokuda; Kiyotaka Sasagawa; Toshihiko Noda
Journal:  Sensors (Basel)       Date:  2009-11-17       Impact factor: 3.576

8.  Development of very large electrode arrays for epiretinal stimulation (VLARS).

Authors:  Florian Waschkowski; Stephan Hesse; Anne Christine Rieck; Tibor Lohmann; Claudia Brockmann; Thomas Laube; Norbert Bornfeld; Gabriele Thumann; Peter Walter; Wilfried Mokwa; Sandra Johnen; Gernot Roessler
Journal:  Biomed Eng Online       Date:  2014-02-06       Impact factor: 2.819

9.  A suprachoroidal electrical retinal stimulator design for long-term animal experiments and in vivo assessment of its feasibility and biocompatibility in rabbits.

Authors:  J A Zhou; S J Woo; S I Park; E T Kim; J M Seo; H Chung; S J Kim
Journal:  J Biomed Biotechnol       Date:  2008

10.  Recording Spikes Activity in Cultured Hippocampal Neurons Using Flexible or Transparent Graphene Transistors.

Authors:  Farida Veliev; Zheng Han; Dipankar Kalita; Anne Briançon-Marjollet; Vincent Bouchiat; Cécile Delacour
Journal:  Front Neurosci       Date:  2017-08-28       Impact factor: 4.677

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