Literature DB >> 15871147

Gamma hydroxy butyrate abuse and dependency.

Alejandro Gonzalez1, David J Nutt.   

Abstract

The recreational use of gamma hydroxy butyrate (GHB) has gained popularity over the last decade. GHB was initially sold as a safe body building and fat burning compound. It is now also widely abused by body builders and young ravers. GHB attracts young people due the euphoria that it initially produces, and the claimed increase in sociability and sexual function (it is also known as liquid Ecstasy). Over the last few years, there has been an increase in the number of cases of GHB intoxication, dependence and severe withdrawal, as reported in medical literature. The situation is complicated by the use of GHB analogues, other toxic chemicals that are easily converted into GHB. GHB has recently been classified as a class 'C' drug in the UK, but no provisions were made in relation to GHB analogues. GHB has been increasingly used in rape cases due to its capacity to produce intoxication and amnesia. The management of patients dependent on GHB is rather complicated due to the high doses of medication that they require to control withdrawal symptoms.

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Year:  2005        PMID: 15871147     DOI: 10.1177/0269881105049041

Source DB:  PubMed          Journal:  J Psychopharmacol        ISSN: 0269-8811            Impact factor:   4.153


  20 in total

1.  An interactive lesson in acid/base and pro-drug chemistry using sodium gamma-hydroxybutyrate and commercial test coasters.

Authors:  Nathaniel A Page; Meaghan Paganelli; Kathleen M K Boje; Ho-Leung Fung
Journal:  Am J Pharm Educ       Date:  2007-06-15       Impact factor: 2.047

Review 2.  Safety overview of postmarketing and clinical experience of sodium oxybate (Xyrem): abuse, misuse, dependence, and diversion.

Authors:  Y Grace Wang; Todd J Swick; Lawrence P Carter; Michael J Thorpy; Neal L Benowitz
Journal:  J Clin Sleep Med       Date:  2009-08-15       Impact factor: 4.062

3.  Behavioral effects of gamma-hydroxybutyrate, its precursor gamma-butyrolactone, and GABA(B) receptor agonists: time course and differential antagonism by the GABA(B) receptor antagonist 3-aminopropyl(diethoxymethyl)phosphinic acid (CGP35348).

Authors:  Wouter Koek; Susan L Mercer; Andrew Coop; Charles P France
Journal:  J Pharmacol Exp Ther       Date:  2009-06-29       Impact factor: 4.030

4.  Effect of γ-hydroxybutyrate (GHB) on driving as measured by a driving simulator.

Authors:  Evangelia Liakoni; Delia A Dempsey; Matthew Meyers; Nancy G Murphy; Dary Fiorentino; Christopher Havel; Christine Haller; Neal L Benowitz
Journal:  Psychopharmacology (Berl)       Date:  2018-09-19       Impact factor: 4.530

Review 5.  Pharmacological Treatment in γ-Hydroxybutyrate (GHB) and γ-Butyrolactone (GBL) Dependence: Detoxification and Relapse Prevention.

Authors:  Rama M Kamal; Martijn S van Noorden; Wim Wannet; Harmen Beurmanjer; Boukje A G Dijkstra; Arnt Schellekens
Journal:  CNS Drugs       Date:  2017-01       Impact factor: 5.749

6.  Butanediol Conversion to Gamma-Hydroxybutyrate Markedly Reduced by the Alcohol Dehydrogenase Blocker Fomepizole.

Authors:  Evangelia Liakoni; Hallam Gugelmann; Delia A Dempsey; Timothy J Wiegand; Christopher Havel; Peyton Jacob; Neal L Benowitz
Journal:  Clin Pharmacol Ther       Date:  2019-01-08       Impact factor: 6.875

7.  Sodium oxybate in the treatment of alcohol withdrawal syndrome: a randomized double-blind comparative study versus oxazepam. The GATE 1 trial.

Authors:  Fabio Caputo; Katrin Skala; Antonio Mirijello; Anna Ferrulli; Henriette Walter; Otto Lesch; Giovanni Addolorato
Journal:  CNS Drugs       Date:  2014-08       Impact factor: 5.749

8.  Area-level socioeconomic status in relation to outcomes in gamma-hydroxybutyrate intoxication.

Authors:  Ilene B Anderson; Susan Y Kim-Katz; Jo Ellen Dyer; Gillian E Earnest; John P Lamb; Paul D Blanc
Journal:  Clin Toxicol (Phila)       Date:  2009-01       Impact factor: 4.467

9.  Cataleptic effects of gamma-hydroxybutyrate (GHB) and baclofen in mice: mediation by GABA(B) receptors, but differential enhancement by N-methyl-d-aspartate (NMDA) receptor antagonists.

Authors:  Wouter Koek; Charles P France
Journal:  Psychopharmacology (Berl)       Date:  2008-04-30       Impact factor: 4.530

10.  Systematic assessment of gamma hydroxybutyrate (GHB) effects during and after acute intoxication.

Authors:  Susan Y Kim; Judith C Barker; Ilene B Anderson; Jo Ellen Dyer; Gillian Earnest; Paul D Blanc
Journal:  Am J Addict       Date:  2008 Jul-Aug
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