Literature DB >> 18612887

Systematic assessment of gamma hydroxybutyrate (GHB) effects during and after acute intoxication.

Susan Y Kim1, Judith C Barker, Ilene B Anderson, Jo Ellen Dyer, Gillian Earnest, Paul D Blanc.   

Abstract

We adapted and tested a previously published questionnaire battery eliciting sensory and cognitive symptoms during (acute) and immediately after (post-acute) GHB intoxication. Studying 125 GHB users, we assessed the instrument's internal consistency using Cronbach's alpha (CA) and responsiveness to change comparing acute and post-acute symptoms. The final 14-item battery demonstrated good internal consistency (CA >or= 0.85, both acute and post-acute). The median symptom score (possible range 0-64) was 30 (acute) and 6 (post-acute; difference p < 0.001). This modified substance-specific symptom battery, which is easily administered, demonstrated excellent performance characteristics. It can be used to study GHB and, potentially, related drugs of abuse.

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Year:  2008        PMID: 18612887      PMCID: PMC2759403          DOI: 10.1080/10550490802138988

Source DB:  PubMed          Journal:  Am J Addict        ISSN: 1055-0496


  16 in total

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2.  Designing a gamma hydroxybutyrate (GHB) structured telephone-administered survey instrument.

Authors:  Jo E Dyer; Ilene Anderson; Susan Kim; Paul Blanc; Judith Barker
Journal:  J Med Toxicol       Date:  2007-03

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4.  Gamma-hydroxybutyrate: an emerging drug of abuse that causes physical dependence.

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5.  Chronic nicotine and smoke treatment modulate dopaminergic activities in ventral tegmental area and nucleus accumbens and the gamma-aminobutyric acid type B receptor expression of the rat prefrontal cortex.

Authors:  Shu-Peng Li; Moon Seok Park; Jong Hun Kim; Myeong Ok Kim
Journal:  J Neurosci Res       Date:  2004-12-15       Impact factor: 4.164

Review 6.  Gamma hydroxy butyrate abuse and dependency.

Authors:  Alejandro Gonzalez; David J Nutt
Journal:  J Psychopharmacol       Date:  2005-03       Impact factor: 4.153

7.  Clinical course of gamma-hydroxybutyrate overdose.

Authors:  R L Chin; K A Sporer; B Cullison; J E Dyer; T D Wu
Journal:  Ann Emerg Med       Date:  1998-06       Impact factor: 5.721

8.  Baclofen antagonizes nicotine-, cocaine-, and morphine-induced dopamine release in the nucleus accumbens of rat.

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9.  The GABAB receptor agonists baclofen and CGP44532 decreased nicotine self-administration in the rat.

Authors:  Neil E Paterson; Wolfgang Froestl; Athina Markou
Journal:  Psychopharmacology (Berl)       Date:  2003-11-11       Impact factor: 4.530

10.  Role of gamma-aminobutyric acid (GABA) and metabotropic glutamate receptors in nicotine reinforcement: potential pharmacotherapies for smoking cessation.

Authors:  Athina Markou; Neil E Paterson; Svetlana Semenova
Journal:  Ann N Y Acad Sci       Date:  2004-10       Impact factor: 5.691

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  1 in total

Review 1.  Illicit gamma-hydroxybutyrate (GHB) and pharmaceutical sodium oxybate (Xyrem): differences in characteristics and misuse.

Authors:  Lawrence P Carter; Daniel Pardi; Jane Gorsline; Roland R Griffiths
Journal:  Drug Alcohol Depend       Date:  2009-06-02       Impact factor: 4.492

  1 in total

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