BACKGROUND: Epidemiological studies have reported inconsistent associations between cardiovascular risk factors and the occurrence of age-related maculopathy (ARM). METHODS: In the baseline examination of the Muenster Aging and Retina Study (MARS), we assessed this potential relationship in 1060 subjects who underwent clinical and ophthalmologic examinations. The ARM status was graded according to international standardized classifications. RESULTS: There were 974 eye pairs available for analysis. Smoking, hypertension, hypercholesterolemia, and a history of myocardial infarction or stroke were found significantly more often in patients with ARM. There were no statistically significant multivariate associations between overweight, diabetes, or a history of myocardial infarction or stroke. CONCLUSIONS: Our results confirm previous epidemiological studies pointing to a potential role of atherosclerotic processes in the development of ARM.
BACKGROUND: Epidemiological studies have reported inconsistent associations between cardiovascular risk factors and the occurrence of age-related maculopathy (ARM). METHODS: In the baseline examination of the Muenster Aging and Retina Study (MARS), we assessed this potential relationship in 1060 subjects who underwent clinical and ophthalmologic examinations. The ARM status was graded according to international standardized classifications. RESULTS: There were 974 eye pairs available for analysis. Smoking, hypertension, hypercholesterolemia, and a history of myocardial infarction or stroke were found significantly more often in patients with ARM. There were no statistically significant multivariate associations between overweight, diabetes, or a history of myocardial infarction or stroke. CONCLUSIONS: Our results confirm previous epidemiological studies pointing to a potential role of atherosclerotic processes in the development of ARM.
Authors: Redmer van Leeuwen; M Kamran Ikram; Johannes R Vingerling; Jacqueline C M Witteman; Albert Hofman; Paulus T V M de Jong Journal: Invest Ophthalmol Vis Sci Date: 2003-09 Impact factor: 4.799
Authors: Redmer van Leeuwen; Caroline C W Klaver; Johannes R Vingerling; Albert Hofman; Cornelia M van Duijn; Bruno H Ch Stricker; Paulus T V M de Jong Journal: Am J Ophthalmol Date: 2004-04 Impact factor: 5.258
Authors: Sandra C Tomany; Jie Jin Wang; Redmer Van Leeuwen; Ronald Klein; Paul Mitchell; Johannes R Vingerling; Barbara E K Klein; Wayne Smith; Paulus T V M De Jong Journal: Ophthalmology Date: 2004-07 Impact factor: 12.079
Authors: A C Bird; N M Bressler; S B Bressler; I H Chisholm; G Coscas; M D Davis; P T de Jong; C C Klaver; B E Klein; R Klein Journal: Surv Ophthalmol Date: 1995 Mar-Apr Impact factor: 6.048