| Literature DB >> 15863320 |
Paul G Wyatt1, Michael J Allen, Alan D Borthwick, Dave E Davies, Anne M Exall, Richard J D Hatley, Wendy R Irving, David G Livermore, Neil D Miller, Fabrizio Nerozzi, Steve L Sollis, Anna Katrin Szardenings.
Abstract
This paper covers efforts to discover orally active potent and selective oxytocin antagonists. Screening pooled libraries identified a novel series of 2,5-diketopiperazine derivatives with antagonist activity at the human oxytocin receptor. We report the initial structure-activity relationship investigations and the determination of the stereochemistry of the most potent compounds.Entities:
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Year: 2005 PMID： 15863320 DOI： 10.1016/j.bmcl.2005.03.045
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823