| Literature DB >> 15856240 |
Klaus Kurt Gast1, Wolfgang G Schreiber, Annette Herweling, Frank Lehmann, Gabor Erdös, Joerg Schmiedeskamp, Hans-Ulrich Kauczor, Balthasar Eberle.
Abstract
The aim of this study was to validate oxygen-sensitive 3He-MRI in noninvasive determination of the regional, two- and three-dimensional distribution of oxygen partial pressure. In a gas-filled elastic silicon ventilation bag used as a lung phantom, oxygen sensitive two- and three-dimensional 3He-MRI measurements were performed at different oxygen concentrations which had been equilibrated in a range of normal and pathologic values. The oxygen partial pressure distribution was determined from 3He-MRI using newly developed software allowing for mapping of oxygen partial pressure. The reference bulk oxygen partial pressure inside the phantom was measured by conventional respiratory gas analysis. In two-dimensional measurements, image-based and gas-analysis results correlated with r=0.98; in three-dimensional measurements the between-methods correlation coefficient was r=0.89. The signal-to-noise ratio of three-dimensional measurements was about half of that of two-dimensional measurements and became critical (below 3) in some data sets. Oxygen-sensitive 3He-MRI allows for noninvasive determination of the two- and three-dimensional distribution of oxygen partial pressure in gas-filled airspaces.Entities:
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Year: 2005 PMID： 15856240 DOI： 10.1007/s00330-005-2778-x
Source DB: PubMed Journal: Eur Radiol ISSN： 0938-7994 Impact factor: 5.315