BACKGROUND: The noninvasive detection of restenosis after percutaneous coronary intervention (PCI) remains a clinical challenge. Previous studies have shown that magnetocardiograms reveal obvious changes in patients with coronary artery disease (CAD) and normal electrocardiogram (ECG) at rest. HYPOTHESIS: The present study aimed to evaluate the potential of magnetocardiography (MCG) for the detection of electrophysiological changes in the course of successful PCI. METHODS: Twelve-lead ECG and unshielded four-channel MCG (SQUID AG, Essen, Germany) were registered at nine prethoracic sites in 50 patients with CAD (62 +/- 10 years; EF = 76 +/- 11%; registration: before, 24 hours, and 1 month (n = 25) after PCI) and 57 normals (51 +/- 9 years). Current density vector (CDV) maps were reconstructed within the ST-T interval and classified from category 0 (normal) to category 4 (grossly abnormal). In both groups and at all registration times, the percentage of each category of maps was calculated and compared. RESULTS: Most CDV maps of normals were classified as category 0, 1, or 2 compared to CAD patients before PCI with most maps of category 3 and 4 (P < 0.0005). Twenty-four hours after PCI, more maps were classified as category 2 (P < 0.05) and less as category 4 (P < 0.005). One month after PCI the MCG results further improved: more maps were classified as category 1 (P < 0.05) and 2 (P < 0.005) and less maps as category 4 (P < 0.0001). The ECG remained unchanged in the course of PCI. CONCLUSION: Unshielded four-channel MCG reveals obvious changes in the course of successful PCI on the basis of CDV map reconstruction during repolarization. The method seems to be suitable for the follow-up of patients after PCI.
BACKGROUND: The noninvasive detection of restenosis after percutaneous coronary intervention (PCI) remains a clinical challenge. Previous studies have shown that magnetocardiograms reveal obvious changes in patients with coronary artery disease (CAD) and normal electrocardiogram (ECG) at rest. HYPOTHESIS: The present study aimed to evaluate the potential of magnetocardiography (MCG) for the detection of electrophysiological changes in the course of successful PCI. METHODS: Twelve-lead ECG and unshielded four-channel MCG (SQUID AG, Essen, Germany) were registered at nine prethoracic sites in 50 patients with CAD (62 +/- 10 years; EF = 76 +/- 11%; registration: before, 24 hours, and 1 month (n = 25) after PCI) and 57 normals (51 +/- 9 years). Current density vector (CDV) maps were reconstructed within the ST-T interval and classified from category 0 (normal) to category 4 (grossly abnormal). In both groups and at all registration times, the percentage of each category of maps was calculated and compared. RESULTS: Most CDV maps of normals were classified as category 0, 1, or 2 compared to CAD patients before PCI with most maps of category 3 and 4 (P < 0.0005). Twenty-four hours after PCI, more maps were classified as category 2 (P < 0.05) and less as category 4 (P < 0.005). One month after PCI the MCG results further improved: more maps were classified as category 1 (P < 0.05) and 2 (P < 0.005) and less maps as category 4 (P < 0.0001). The ECG remained unchanged in the course of PCI. CONCLUSION: Unshielded four-channel MCG reveals obvious changes in the course of successful PCI on the basis of CDV map reconstruction during repolarization. The method seems to be suitable for the follow-up of patients after PCI.
Authors: Birgit Hailer; Illja Chaikovsky; Sabine Auth-Eisernitz; Harald Schäfer; Fritz Steinberg; Dietrich H W Grönemeyer Journal: Clin Cardiol Date: 2003-10 Impact factor: 2.882
Authors: W G Hundley; L D Hillis; C A Hamilton; R J Applegate; D M Herrington; G D Clarke; G A Braden; M S Thomas; R A Lange; R M Peshock; K M Link Journal: Circulation Date: 2000-05-23 Impact factor: 29.690
Authors: Adelaide M Arruda-Olson; Eldyn M Juracan; Douglas W Mahoney; Robert B McCully; Veronique L Roger; Patricia A Pellikka Journal: J Am Coll Cardiol Date: 2002-02-20 Impact factor: 24.094
Authors: M B Honan; J R Bengtson; D B Pryor; D S Rendall; R S Stack; T Hinohara; T N Skelton; R M Califf; M A Hlatky; D B Mark Journal: Circulation Date: 1989-12 Impact factor: 29.690
Authors: O Kittnar; J Slavícek; M Vávrová; M Barna; A Dohnalová; A Málková; M Aschermann; J Humhal; J Hradec; J Král Journal: Physiol Res Date: 1993 Impact factor: 1.881