| Literature DB >> 7545492 |
M Sundvall1, J Jirholt, H T Yang, L Jansson, A Engström, U Pettersson, R Holmdahl.
Abstract
B10.RIII mice develop chronic and relapsing experimental autoimmune encephalomyelitis (EAE) after immunization with the myelin basic protein (MBP) peptide 89-101. The disease is associated with the major histocompatibility complex (MHC) (eae1). We have now investigated the importance of non-MHC regions for the EAE susceptibility in a cross between RIIIS/J and B10.RIII mice which share the MHC region but differ in disease susceptibility. Linkage analysis using microsatellite markers spanning the genome identified a region (eae2) on chromosome 15 which showed linkage to disease (P = 0.0002). Our data also suggest linkage to a second region (eae3) on chromosome 3 (P = 0.0024), and provide evidence for locus interactions between eae2 and eae3. These results provide clues to the genetic basis of multiple sclerosis.Entities:
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Year: 1995 PMID： 7545492 DOI： 10.1038/ng0795-313
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330