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Literature DB >> 15817768

Immunization with recombinant surface antigen P50 of Babesia gibsoni expressed in insect cells induced parasite growth inhibition in dogs.

Shinya Fukumoto¹, Yoh Tamaki, Hiroaki Shirafuji, Shinji Harakawa, Hiroshi Suzuki, Xuenan Xuan.

Abstract

This is a report of a vaccine trial directed against Babesia gibsoni infection in dogs with the use of the recombinant antigen P50. Dogs immunized with P50 showed partial protection manifested as a significantly low level of parasitemia. The results indicated that P50 is a primary vaccine candidate molecule against canine B. gibsoni infection.

Entities: Disease Species

Mesh：

Substances：

Year: 2005 PMID： 15817768 PMCID： PMC1074387 DOI： 10.1128/CDLI.12.4.557-559.2005

Source DB: PubMed Journal: Clin Diagn Lab Immunol ISSN： 1071-412X

14 in total

Review 1. Induction of CD8+ T cells using heterologous prime-boost immunisation strategies.

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Journal: Immunol Rev Date: 1999-08 Impact factor: 12.988

Review 2. Designing blood-stage vaccines against Babesia bovis and B. bigemina.

Authors: W C Brown; G H Palmer
Journal: Parasitol Today Date: 1999-07

Review 3. Advances and prospects for subunit vaccines against protozoa of veterinary importance.

Authors: M C Jenkins
Journal: Vet Parasitol Date: 2001-11-22 Impact factor: 2.738

4. Inhibitory effect of antiserum to surface antigen P50 of Babesia gibsoni on growth of parasites in severe combined immunodeficiency mice given canine red blood cells.

Authors: Shinya Fukumoto; Xuenan Xuan; Noriyuki Takabatake; Ikuo Igarashi; Chihiro Sugimoto; Kozo Fujisaki; Hideyuki Nagasawa; Takeshi Mikami; Hiroshi Suzuki
Journal: Infect Immun Date: 2004-03 Impact factor: 3.441

5. Canine piroplasmosis due to Babesia gibsoni: clinical and morphological aspects.

Authors: R Casapulla; L Baldi; V Avallone; R Sannino; L Pazzanese; V Mizzoni
Journal: Vet Rec Date: 1998-02-14 Impact factor: 2.695

6. Enhanced immunogenicity of CD4(+) t-cell responses and protective efficacy of a DNA-modified vaccinia virus Ankara prime-boost vaccination regimen for murine tuberculosis.

Authors: H McShane; R Brookes; S C Gilbert; A V Hill
Journal: Infect Immun Date: 2001-02 Impact factor: 3.441

7. Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara.

Authors: J Schneider; S C Gilbert; T J Blanchard; T Hanke; K J Robson; C M Hannan; M Becker; R Sinden; G L Smith; A V Hill
Journal: Nat Med Date: 1998-04 Impact factor: 53.440

8. Development of a preventive vaccine for Ebola virus infection in primates.

Authors: N J Sullivan; A Sanchez; P E Rollin; Z Y Yang; G J Nabel
Journal: Nature Date: 2000-11-30 Impact factor: 49.962

9. Clinical, anatomic, and immunopathologic characterization of Babesia gibsoni infection in the domestic dog (Canis familiaris).

Authors: E J Wozniak; B C Barr; J W Thomford; I Yamane; S P McDonough; P F Moore; D Naydan; T W Robinson; P A Conrad
Journal: J Parasitol Date: 1997-08 Impact factor: 1.276

10. High-level expression of truncated surface antigen P50 of Babesia gibsoni in insect cells by baculovirus and evaluation of its immunogenicity and antigenicity.

Authors: Shinya Fukumoto; Xuenan Xuan; Kimie Kadota; Ikuo Igarashi; Chihiro Sugimoto; Kozo Fujisaki; Hideyuki Nagasawa; Takeshi Mikami; Hiroshi Suzuki
Journal: Clin Diagn Lab Immunol Date: 2003-07

4 in total

Review 4. The Etiology, Incidence, Pathogenesis, Diagnostics, and Treatment of Canine Babesiosis Caused by Babesia gibsoni Infection.

Authors: Martina Karasová; Csilla Tóthová; Simona Grelová; Mária Fialkovičová
Journal: Animals (Basel) Date: 2022-03-16 Impact factor: 2.752