| Literature DB >> 10566139 |
J Schneider1, S C Gilbert, C M Hannan, P Dégano, E Prieur, E G Sheu, M Plebanski, A V Hill.
Abstract
One of the current challenges in vaccine design is the development of antigen delivery systems or vaccination strategies that induce high protective levels of CD8+ T cells. These cells are crucial for protection against certain tumours and intracellular pathogens such as the liver-stage parasite of malaria. A liver-stage malaria vaccine should therefore include CD8+ T-cell-inducing components. This review provides an overview of prime-boost immunisation strategies that result in protective CD8+ T-cell responses against malaria with an emphasis on work from our laboratory. Possible mechanisms explaining why heterologous prime-boost strategies, in particular boosting with replication-impaired recombinant poxviruses, are so effective are discussed.Entities:
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Year: 1999 PMID： 10566139 DOI： 10.1111/j.1600-065x.1999.tb01326.x
Source DB: PubMed Journal: Immunol Rev ISSN： 0105-2896 Impact factor: 12.988