Literature DB >> 15812784

Generation of novel landomycins M and O through targeted gene disruption.

Andriy Luzhetskyy1, Lili Zhu, Miranda Gibson, Marta Fedoryshyn, Clemens Dürr, Carsten Hofmann, Dirk Hoffmeister, Bohdan Ostash, Cynthia Mattingly, Val Adams, Victor Fedorenko, Jürgen Rohr, Andreas Bechthold.   

Abstract

Two genes from Streptomyces cyanogenous S136 that encode the reductase LanZ4 and the hydroxylase LanZ5, which are involved in landomycin A biosynthesis, were characterized by targeted gene inactivation. Analyses of the corresponding mutants as well as complementation experiments have allowed us to show that LanZ4 and LanZ5 are responsible for the unique C-11-hydroxylation that occurs during landomycin biosynthesis. Compounds accumulated by the lanZ4/Z5 mutants are the previously described landomycin F and the new landomycins M and O.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 15812784     DOI： 10.1002/cbic.200400316

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  13 in total

1.  Landomycins P-W, cytotoxic angucyclines from Streptomyces cyanogenus S-136.

Authors:  Khaled A Shaaban; Sowmyalakshmi Srinivasan; Raj Kumar; Chendil Damodaran; Jürgen Rohr
Journal:  J Nat Prod       Date:  2010-12-28       Impact factor: 4.050

Review 2.  A comprehensive review of glycosylated bacterial natural products.

Authors:  Sherif I Elshahawi; Khaled A Shaaban; Madan K Kharel; Jon S Thorson
Journal:  Chem Soc Rev       Date:  2015-11-07       Impact factor: 54.564

3.  Rapid generation of hydrogen peroxide contributes to the complex cell death induction by the angucycline antibiotic landomycin E.

Authors:  Rostyslav R Panchuk; Lilya V Lehka; Alessio Terenzi; Bohdan P Matselyukh; Jürgen Rohr; Amit K Jha; Theresa Downey; Iryna J Kril; Irene Herbacek; Sushilla van Schoonhoven; Petra Heffeter; Rostyslav S Stoika; Walter Berger
Journal:  Free Radic Biol Med       Date:  2017-02-09       Impact factor: 7.376

4.  On the acceptor substrate of C-glycosyltransferase UrdGT2: three prejadomycin C-Glycosides from an engineered mutant of Streptomyces globisporus 1912 DeltalndE(urdGT2).

Authors:  Irfan Baig; Madan Kharel; Anton Kobylyanskyy; Lili Zhu; Yuriy Rebets; Bohdan Ostash; Andriy Luzhetskyy; Andreas Bechthold; Victor A Fedorenko; Jürgen Rohr
Journal:  Angew Chem Int Ed Engl       Date:  2006-11-27       Impact factor: 15.336

5.  Properties of lanK-based regulatory circuit involved in landomycin biosynthesis in Streptomyces cyanogenus S136.

Authors:  B Ostash; I Ostash; L Zhu; M K Kharel; A Luzhetskiĭ; A Bechthold; S Walker; J Rohr; V Fedorenko
Journal:  Genetika       Date:  2010-05

Review 6.  Delineation of gilvocarcin, jadomycin, and landomycin pathways through combinatorial biosynthetic enzymology.

Authors:  Madan K Kharel; Jürgen Rohr
Journal:  Curr Opin Chem Biol       Date:  2012-03-30       Impact factor: 8.822

7.  Genetic manipulation of pathway regulation for overproduction of angucycline-like antibiotic auricin in Streptomyces aureofaciens CCM 3239.

Authors:  Renata Novakova; Alena Rehakova; Lubomira Feckova; Peter Kutas; Renata Knischova; Jan Kormanec
Journal:  Folia Microbiol (Praha)       Date:  2011-05-17       Impact factor: 2.099

8.  Generation of new landomycins with altered saccharide patterns through over-expression of the glycosyltransferase gene lanGT3 in the biosynthetic gene cluster of landomycin A in Streptomyces cyanogenus S-136.

Authors:  Lili Zhu; Andriy Luzhetskyy; Martha Luzhetska; Cynthia Mattingly; Val Adams; Andreas Bechthold; Jürgen Rohr
Journal:  Chembiochem       Date:  2007-01-02       Impact factor: 3.164

9.  11-Deoxylandomycinone and landomycins X-Z, new cytotoxic angucyclin(on)es from a Streptomyces cyanogenus K62 mutant strain.

Authors:  Khaled A Shaaban; Chris Stamatkin; Chendil Damodaran; Jürgen Rohr
Journal:  J Antibiot (Tokyo)       Date:  2010-10-27       Impact factor: 2.649

10.  A Novel Nanoconjugate of Landomycin A with C60 Fullerene for Cancer Targeted Therapy: In Vitro Studies.

Authors:  V Bilobrov; V Sokolova; S Prylutska; R Panchuk; O Litsis; V Osetskyi; M Evstigneev; Yu Prylutskyy; M Epple; U Ritter; J Rohr
Journal:  Cell Mol Bioeng       Date:  2018-08-15       Impact factor: 2.321
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.