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Literature DB >> 15780632

Synthesis and in vitro antitumor activity of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains.

Sheng-Li Cao¹, Yu-Ping Feng, Yu-Yang Jiang, Shi-Ying Liu, Guo-Yu Ding, Run-Tao Li.

Abstract

A series of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains were synthesized and tested for their in vitro antitumor activity against human myelogenous leukemia K562 cells. Among them, (3,4-dihydro-2-methyl-4-oxoquinazolin-6-yl)methyl 4-(4-fluorophenyl)piperazine-1-carbodithioate 8q exhibited significant inhibitory activity against K562 cells with IC(50) value of 0.5 microM.

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Year: 2005 PMID： 15780632 DOI： 10.1016/j.bmcl.2005.01.083

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

24 in total

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Journal: Bioorg Med Chem Date: 2015-07-04 Impact factor: 3.641

2. DDQ in mechanochemical C-N coupling reactions.

Authors: Shyamal Kanti Bera; Rosalin Bhanja; Prasenjit Mal
Journal: Beilstein J Org Chem Date: 2022-06-01 Impact factor: 2.544

3. 2-(2,3-Dioxoindolin-1-yl)ethyl 4-(4-nitro-phen-yl)piperazine-1-carbodithio-ate.

Authors: Yao Wang; Chong-Qing Wan; Sheng-Li Cao; Tingting Zheng
Journal: Acta Crystallogr Sect E Struct Rep Online Date: 2010-08-11

4. Synthesis of some new tricyclic 4(3H)-quinazolinone derivatives.

Authors: E Jafari; G A Khodarahmi; G H Hakimelahi; F Y Tsai; F Hassanzadeh
Journal: Res Pharm Sci Date: 2011-07

5. 2-(5-Fluoro-2,3-dioxoindolin-1-yl)ethyl 4-methyl-piperazine-1-carbodithio-ate.

Authors: Yao Wang; Hui-Hui Lin; Sheng-Li Cao
Journal: Acta Crystallogr Sect E Struct Rep Online Date: 2011-12-10

6. Amberlite-15 promoted an unprecedented aza Michael rearrangement for one pot synthesis of dihydroquinazolinone compounds.

Authors: V Narayana Murthy; Satish P Nikumbh; Krishnaji Tadiparthi; M V Madhubabu; Subba Rao Jammula; L Vaikunta Rao; Akula Raghunadh
Journal: RSC Adv Date: 2018-06-19 Impact factor: 4.036

Synthesis and in vitro antitumor activity of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains.

1. Design, synthesis and cytotoxicity studies of dithiocarbamate ester derivatives of emetine in prostate cancer cell lines.

2. DDQ in mechanochemical C-N coupling reactions.

3. 2-(2,3-Dioxoindolin-1-yl)ethyl 4-(4-nitro-phen-yl)piperazine-1-carbodithio-ate.

4. Synthesis of some new tricyclic 4(3H)-quinazolinone derivatives.

5. 2-(5-Fluoro-2,3-dioxoindolin-1-yl)ethyl 4-methyl-piperazine-1-carbodithio-ate.

6. Amberlite-15 promoted an unprecedented aza Michael rearrangement for one pot synthesis of dihydroquinazolinone compounds.

7. Antibacterial, antifungal and cytotoxic evaluation of some new quinazolinone derivatives.

8. N-(2,5-Dimeth-oxy-phen-yl)-6-nitro-quinazolin-4-amine.

9. Antibacterial, antifungal and cytotoxic evaluation of some new 2,3-disubstituted 4(3H)-quinazolinone derivatives.

10. Synthesis, Characterization, and Anti-Inflammatory Activity of Newer Quinazolinone Analogs.