Literature DB >> 15777263

Albumin nanoparticles for the intravitreal delivery of anticytomegaloviral drugs.

J M Irache1, M Merodio, A Arnedo, M A Camapanero, M Mirshahi, S Espuelas.   

Abstract

Albumin nanoparticles (NP) were proved to be effective and safe carriers for delivering anticytomegaloviral compounds in the vitreous. NP improved the antiviral activity of both ganciclovir and the phosphodiester oligonucleotide analog to formivirsen. NP appeared to be fusogenic carriers able to target the nucleus of cells. In addition, these drug carriers were well tolerated when administered by the intravitreal route and did not induce autoimmune reactions.

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Year:  2005        PMID： 15777263     DOI： 10.2174/1389557053175335

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  23 in total

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