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Literature DB >> 1576878

Integrating chromosome structure with function.

Abstract

Historically, the metaphase chromosome and its architecture has been viewed as the ultimate representation of a non-functional inactive chromatin state. Recent studies of centromere (kinetochore) function in concert with studies of the placement and function of several classes of chromosomal proteins now call for a reevaluation of this view. In this article a model of chromosome structure with functional correlates is presented. Evidence for the existence of a functional chromosomal region, the "Surface Domain" is discussed.

Mesh：

Year: 1992 PMID： 1576878 DOI： 10.1007/bf00346003

Source DB: PubMed Journal: Chromosoma ISSN： 0009-5915 Impact factor: 4.316

31 in total

1. Genes occupy a fixed and symmetrical position on sister chromatids.

Authors: M Baumgartner; B Dutrillaux; N Lemieux; A Lilienbaum; D Paulin; E Viegas-Péquignot
Journal: Cell Date: 1991-02-22 Impact factor: 41.582

2. Detection of distinct structural domains within the primary constriction using autoantibodies.

Authors: J B Rattner; B G Kingwell; M J Fritzler
Journal: Chromosoma Date: 1988 Impact factor: 4.316

3. Metaphase chromosome structure: the role of nonhistone proteins.

Authors: U K Laemmli; S M Cheng; K W Adolph; J R Paulson; J A Brown; W R Baumbach
Journal: Cold Spring Harb Symp Quant Biol Date: 1978

4. Redistribution of U-snRNPs during mitosis.

Authors: D L Spector; H C Smith
Journal: Exp Cell Res Date: 1986-03 Impact factor: 3.905

5. The redistribution of a conserved nuclear envelope protein during the cell cycle suggests a pathway for chromosome condensation.

Authors: F D McKeon; D L Tuffanelli; S Kobayashi; M W Kirschner
Journal: Cell Date: 1984-01 Impact factor: 41.582

6. Localization of nucleolar phosphoproteins B23 and C23 during mitosis.

Authors: R Ochs; M Lischwe; P O'Leary; H Busch
Journal: Exp Cell Res Date: 1983-06 Impact factor: 3.905

7. Analysis of the distribution of the INCENPs throughout mitosis reveals the existence of a pathway of structural changes in the chromosomes during metaphase and early events in cleavage furrow formation.

Authors: W C Earnshaw; C A Cooke
Journal: J Cell Sci Date: 1991-04 Impact factor: 5.285

8. A perichromosomal region contains proteins phosphorylated during mitosis in Xenopus laevis cells.

Authors: S M Dilworth
Journal: J Cell Sci Date: 1991-03 Impact factor: 5.285

9. Chromosomes move poleward in anaphase along stationary microtubules that coordinately disassemble from their kinetochore ends.

Authors: G J Gorbsky; P J Sammak; G G Borisy
Journal: J Cell Biol Date: 1987-01 Impact factor: 10.539

10. The motor for poleward chromosome movement in anaphase is in or near the kinetochore.

Authors: R B Nicklas
Journal: J Cell Biol Date: 1989-11 Impact factor: 10.539

14 in total

1. MSA-36: a chromosomal and mitotic spindle-associated protein.

Authors: J B Rattner; T Wang; G Mack; M J Fritzler; L Martin; D Valencia
Journal: Chromosoma Date: 1992-10 Impact factor: 4.316

Review 2. The perichromosomal layer.

Authors: Aaron A Van Hooser; Patrick Yuh; Rebecca Heald
Journal: Chromosoma Date: 2005-11-15 Impact factor: 4.316

Integrating chromosome structure with function.

1. Genes occupy a fixed and symmetrical position on sister chromatids.

2. Detection of distinct structural domains within the primary constriction using autoantibodies.

3. Metaphase chromosome structure: the role of nonhistone proteins.

4. Redistribution of U-snRNPs during mitosis.

5. The redistribution of a conserved nuclear envelope protein during the cell cycle suggests a pathway for chromosome condensation.

6. Localization of nucleolar phosphoproteins B23 and C23 during mitosis.

7. Analysis of the distribution of the INCENPs throughout mitosis reveals the existence of a pathway of structural changes in the chromosomes during metaphase and early events in cleavage furrow formation.

8. A perichromosomal region contains proteins phosphorylated during mitosis in Xenopus laevis cells.

9. Chromosomes move poleward in anaphase along stationary microtubules that coordinately disassemble from their kinetochore ends.

10. The motor for poleward chromosome movement in anaphase is in or near the kinetochore.

1. MSA-36: a chromosomal and mitotic spindle-associated protein.

Review 2. The perichromosomal layer.

Review 3. Atomic force microscopy for imaging human metaphase chromosomes.

4. Changes in chromosomal ultrastructure during the cell cycle.

Review 5. Autoantibodies to components of the mitotic apparatus.

6. Elasticity measurements show the existence of thin rigid cores inside mitotic chromosomes.

7. Relative distribution of rDNA and proteins of the RNA polymerase I transcription machinery at chromosomal NORs.

8. Topographic changes in a heterochromatic chromosome block in humans (15P) during formation of the nucleolus.

Review 9. Chromosome research--look forward to 2001.

10. The structure of human S-phase chromosome fibres.