| Literature DB >> 7551545 |
Abstract
Fluorescence in situ hybridization and multispectral confocal laser scanning microscopy revealed a highly dynamic nucleolar-associated chromosome 15 satellite III heterochromatin cluster in humans. This nucleolar-associated DNA was highly decondensed at the metaphase plate compared with its topography at interphase and appeared to act as a centre for the post-mitotic reorganization of the nucleolus. Our data showed unexpected trans-mitotic changes in the topography of this nucleolar-associated satellite III DNA that suggest that this locus-specific heterochromatin superstructure may be involved in nucleolar organization.Entities:
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Year: 1995 PMID: 7551545 DOI: 10.1007/bf00713069
Source DB: PubMed Journal: Chromosome Res ISSN: 0967-3849 Impact factor: 5.239