BACKGROUND AND PURPOSE: Cardiovascular magnetic resonance (CMR) perfusion can accurately detect coronary artery disease (CAD). However, the absence of efficient, easy-to-use and reliable image analysis software is an obstacle to its introduction into clinical practice. The aim of this study was to evaluate new color-encoded semiautomatic software for analysis of first-pass CMR perfusion in comparison to tetrofosmin myocardial single photon emission computed tomography (SPECT), using X-ray angiography as the standard of truth for the detection of CAD. METHODS: Thirty-two patients underwent both SPECT and CMR perfusion at rest and adenosine stress. Twenty of these patients also underwent X-ray angiography. Off-line CMR image analysis consisted of six steps to generate a color display of the myocardial perfusion reserve index (MPRI). The MPRI color-maps were analyzed visually and compared to SPECT. RESULTS: In comparison to X-ray angiography overall accuracy was 87% for CMR and 77% for SPECT perfusion to detect significant CAD (stenosis > or =70%). In comparison with SPECT sensitivity was 80%, specificity 91%, and the overall agreement 89% for CMR. CONCLUSIONS: Post-processing of CMR perfusion data using new semiautomatic software to generate and display the MPRI visually as color-encoded images is feasible and fast. In this study it yielded higher accuracy than SPECT to detect significant CAD on X-ray angiography. Correlation between SPECT and CMR accuracy for detection of perfusion defects was high. This method may accelerate the time-consuming analysis of CMR perfusion data, thus enabling a more widespread clinical utility.
BACKGROUND AND PURPOSE: Cardiovascular magnetic resonance (CMR) perfusion can accurately detect coronary artery disease (CAD). However, the absence of efficient, easy-to-use and reliable image analysis software is an obstacle to its introduction into clinical practice. The aim of this study was to evaluate new color-encoded semiautomatic software for analysis of first-pass CMR perfusion in comparison to tetrofosmin myocardial single photon emission computed tomography (SPECT), using X-ray angiography as the standard of truth for the detection of CAD. METHODS: Thirty-two patients underwent both SPECT and CMR perfusion at rest and adenosine stress. Twenty of these patients also underwent X-ray angiography. Off-line CMR image analysis consisted of six steps to generate a color display of the myocardial perfusion reserve index (MPRI). The MPRI color-maps were analyzed visually and compared to SPECT. RESULTS: In comparison to X-ray angiography overall accuracy was 87% for CMR and 77% for SPECT perfusion to detect significant CAD (stenosis > or =70%). In comparison with SPECT sensitivity was 80%, specificity 91%, and the overall agreement 89% for CMR. CONCLUSIONS: Post-processing of CMR perfusion data using new semiautomatic software to generate and display the MPRI visually as color-encoded images is feasible and fast. In this study it yielded higher accuracy than SPECT to detect significant CAD on X-ray angiography. Correlation between SPECT and CMR accuracy for detection of perfusion defects was high. This method may accelerate the time-consuming analysis of CMR perfusion data, thus enabling a more widespread clinical utility.
Authors: Robert C Hendel; James R Corbett; S James Cullom; E Gordon DePuey; Ernest V Garcia; Timothy M Bateman Journal: J Nucl Cardiol Date: 2002 Jan-Feb Impact factor: 5.952
Authors: J R Panting; P D Gatehouse; G Z Yang; M Jerosch-Herold; N Wilke; D N Firmin; D J Pennell Journal: J Magn Reson Imaging Date: 2001-02 Impact factor: 4.813
Authors: J Schwitter; D Nanz; S Kneifel; K Bertschinger; M Büchi; P R Knüsel; B Marincek; T F Lüscher; G K von Schulthess Journal: Circulation Date: 2001-05-08 Impact factor: 29.690
Authors: J T Keijer; A C van Rossum; M J van Eenige; J J Bax; F C Visser; J J Teule; C A Visser Journal: J Magn Reson Imaging Date: 2000-06 Impact factor: 4.813
Authors: Jonathan R Panting; Peter D Gatehouse; Guang-Zhong Yang; Frank Grothues; David N Firmin; Peter Collins; Dudley J Pennell Journal: N Engl J Med Date: 2002-06-20 Impact factor: 91.245