| Literature DB >> 15741002 |
Peter M Wehmeier1, Stefan Gebhardt, Jörg Schmidtke, Helmut Remschmidt, Johannes Hebebrand, Frank M Theisen.
Abstract
Clozapine is an atypical antipsychotic known to cause considerable weight gain. The extent to which genetic factors determine weight gain is unknown. Here we report on a pair of female monozygotic twins concordant for schizophrenia and mild mental retardation who were treated with clozapine over 5.5 years. One twin gained a total of 53.1 kg and had a weight of 107.5 kg (BMI=38.1 kg/m2) at the end of the observation period. The other twin gained a total of 48.2 kg and finally had a weight of 100.4 kg (BMI=33.8 kg/m2). Because both patients experienced considerable weight gain during treatment, our observation suggests that the antipsychotic-induced weight gain is under strong genetic control.Entities:
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Year: 2005 PMID： 15741002 DOI： 10.1016/j.psychres.2004.02.018
Source DB: PubMed Journal: Psychiatry Res ISSN： 0165-1781 Impact factor: 3.222