BACKGROUND: This study was designed to determine if it was feasible to use a run-to-run algorithm to improve postprandial glucose concentrations in individuals with type 1 diabetes mellitus (T1DM). METHODS: Fourteen subjects were recruited for this 10-week study. During the initial phases of the study, the following information was derived for each subject: basal insulin infusion rates, insulin-to-carbohydrate ratios, insulin correction factors for hyperglycemia, and insulin sensitivities. During the final phases, the algorithm was used to suggest preprandial insulin doses, with a goal of bringing the postprandial glucose into a predetermined target range within 3-7 days. RESULTS: In the single-meal phase (phase 5), 33% of the subject-meal responses were convergent in 3-4 days to a clinically acceptable range, 33% always stayed in range, and 33% had divergent responses, incorrect sensitivities, and/or other mitigating circumstances. In the three-meal phase (phase 6), 41% of the subject-meal responses were convergent in 3-4 days to a clinically acceptable range, 26% were always in range, and 33% had divergent responses, incorrect sensitivities, and/or other mitigating circumstances. CONCLUSIONS: Overall, we were able to safely demonstrate that run-to-run control can be used to manage meal-related insulin in subjects with T1DM.
BACKGROUND: This study was designed to determine if it was feasible to use a run-to-run algorithm to improve postprandial glucose concentrations in individuals with type 1 diabetes mellitus (T1DM). METHODS: Fourteen subjects were recruited for this 10-week study. During the initial phases of the study, the following information was derived for each subject: basal insulin infusion rates, insulin-to-carbohydrate ratios, insulin correction factors for hyperglycemia, and insulin sensitivities. During the final phases, the algorithm was used to suggest preprandial insulin doses, with a goal of bringing the postprandial glucose into a predetermined target range within 3-7 days. RESULTS: In the single-meal phase (phase 5), 33% of the subject-meal responses were convergent in 3-4 days to a clinically acceptable range, 33% always stayed in range, and 33% had divergent responses, incorrect sensitivities, and/or other mitigating circumstances. In the three-meal phase (phase 6), 41% of the subject-meal responses were convergent in 3-4 days to a clinically acceptable range, 26% were always in range, and 33% had divergent responses, incorrect sensitivities, and/or other mitigating circumstances. CONCLUSIONS: Overall, we were able to safely demonstrate that run-to-run control can be used to manage meal-related insulin in subjects with T1DM.
Authors: Daniela Bruttomesso; Anne Farret; Silvana Costa; Maria Cristina Marescotti; Monica Vettore; Angelo Avogaro; Antonio Tiengo; Chiara Dalla Man; Jerome Place; Andrea Facchinetti; Stefania Guerra; Lalo Magni; Giuseppe De Nicolao; Claudio Cobelli; Eric Renard; Alberto Maran Journal: J Diabetes Sci Technol Date: 2009-09-01
Authors: Ivan L Yeoh; Per G Reinhall; Martin C Berg; Howard J Chizeck; Eric J Seibel Journal: J Dyn Syst Meas Control Date: 2017-06-05 Impact factor: 1.372
Authors: H Peter Chase; Francis J Doyle; Howard Zisser; Eric Renard; Revital Nimri; Claudio Cobelli; Bruce A Buckingham; David M Maahs; Stacey Anderson; Lalo Magni; John Lum; Peter Calhoun; Craig Kollman; Roy W Beck Journal: Diabetes Technol Ther Date: 2014-09-04 Impact factor: 6.118
Authors: Lalo Magni; Marco Forgione; Chiara Toffanin; Chiara Dalla Man; Boris Kovatchev; Giuseppe De Nicolao; Claudio Cobelli Journal: J Diabetes Sci Technol Date: 2009-09-01
Authors: Wendy C Bevier; Serena M Fuller; Ryan P Fuller; Richard R Rubin; Eyal Dassau; Francis J Doyle; Lois Jovanovič; Howard C Zisser Journal: Diabetes Technol Ther Date: 2014-05-08 Impact factor: 6.118