Literature DB >> 15734685

Longevity and lineages: toward the integrative biology of degenerative diseases in heart, muscle, and bone.

Kenneth R Chien1, Gerard Karsenty.   

Abstract

Human aging is characterized by debilitating diseases, including heart failure, cardiac pacemaker defects, muscle wasting, and osteoporosis, in heart, skeletal muscle, and bone. Recent studies are identifying pathways for these aging-related diseases by examining how the process of aging influences tissue-specific progenitors and differentiated cell lineages in these organ systems. These advances form a foundation for new therapeutic strategies to delay the onset of aging-related disorders.

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Year:  2005        PMID： 15734685     DOI： 10.1016/j.cell.2005.02.006

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  43 in total

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Journal:  Endocrine       Date:  2014-05-07       Impact factor: 3.633

Review 9.  Senescent cells as a source of inflammatory factors for tumor progression.

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Journal:  Nutr Res Pract       Date:  2010-10-26       Impact factor: 1.926
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