Literature DB >> 15709035

Murine gammaherpesvirus 68 open reading frame 11 encodes a nonessential virion component.

Jessica M Boname1, Janet S May, Philip G Stevenson.   

Abstract

Open reading frame 11 (ORF11) is a conserved gammaherpesvirus gene that remains undefined. We identified the product of murine gammaherpesvirus 68 (MHV-68) ORF11, p43, as a virion component with a predominantly perinuclear distribution in infected cells. MHV-68 lacking p43 grew normally in vitro but showed reduced lytic replication in vivo and a delay in seeding to the spleen. Subsequent latency amplification was normal. Thus, MHV-68 ORF11 encoded a virion component that was important for in vivo lytic replication but dispensable for the establishment of latency.

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Year:  2005        PMID： 15709035      PMCID： PMC548481          DOI： 10.1128/JVI.79.5.3163-3168.2005

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  16 in total

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Journal:  Nat Immunol       Date:  2002-07-08       Impact factor: 25.606

Review 5.  Molecular evolution of the gamma-Herpesvirinae.

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Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2001-04-29       Impact factor: 6.237

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Authors:  H Adler; M Messerle; M Wagner; U H Koszinowski
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7.  Transcription program of murine gammaherpesvirus 68.

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8.  Murine gammaherpesvirus 68 lacking gp150 shows defective virion release but establishes normal latency in vivo.

Authors:  Brigitte D de Lima; Janet S May; Philip G Stevenson
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Authors:  Filipa B Lopes; Susanna Colaco; Janet S May; Philip G Stevenson
Journal:  J Virol       Date:  2004-12       Impact factor: 5.103

10.  Murine gammaherpesvirus 68 lacking thymidine kinase shows severe attenuation of lytic cycle replication in vivo but still establishes latency.

Authors:  Heather M Coleman; Brigitte de Lima; Victoria Morton; Philip G Stevenson
Journal:  J Virol       Date:  2003-02       Impact factor: 5.103
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  9 in total

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2.  Construction and characterization of an infectious murine gammaherpesivrus-68 bacterial artificial chromosome.

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Authors:  Andrew J Davison; Nigel D Stow
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4.  The Epstein-Barr virus LF2 protein inhibits viral replication.

Authors:  Michael A Calderwood; Amy M Holthaus; Eric Johannsen
Journal:  J Virol       Date:  2008-06-18       Impact factor: 5.103

5.  Murine gammaherpesvirus-68 glycoprotein B presents a difficult neutralization target to monoclonal antibodies derived from infected mice.

Authors:  Laurent Gillet; Michael B Gill; Susanna Colaco; Christopher M Smith; Philip G Stevenson
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7.  Murine gammaherpesvirus 68 encoding open reading frame 11 targets TANK binding kinase 1 to negatively regulate the host type I interferon response.

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Review 8.  Coevolution pays off: Herpesviruses have the license to escape the DNA sensing pathway.

Authors:  Markus Stempel; Baca Chan; Melanie M Brinkmann
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9.  The murine gammaherpesvirus-68 gp150 acts as an immunogenic decoy to limit virion neutralization.

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Journal:  PLoS One       Date:  2007-08-08       Impact factor: 3.240
  9 in total

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