Literature DB >> 15542690

Characterization of murine gammaherpesvirus 68 glycoprotein B.

Filipa B Lopes1, Susanna Colaco, Janet S May, Philip G Stevenson.   

Abstract

Murine gammaherpesvirus 68 (MHV-68) glycoprotein B (gB) was identified in purified virions by immunoblotting, immunoprecipitation, and immunoelectron microscopy. It was synthesized as a 120-kDa precursor in infected cells and cleaved into 65-kDa and 55-kDa disulfide-linked subunits close to the time of virion release. The N-linked glycans on the cleaved, virion gB remained partially endoglycosidase H sensitive. The processing of MHV-68 gB therefore appears similar to that of Kaposi's sarcoma-associated herpesvirus gB and human cytomegalovirus gB.

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Year:  2004        PMID： 15542690      PMCID： PMC525018          DOI： 10.1128/JVI.78.23.13370-13375.2004

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


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